| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The purpose of this study is to clarify the signal transduction pathways in cancer cells activated by interaction with platelets and to develop inhibitors against these signaling pathways. I found that direct interaction of platelets and sarcoma cells contributes to tumor malignancy by enhancing both tumor growth and tumor drug resistance, and identified PI3K-Akt pathway as a key signal transduction pathway which causes platelet-mediated tumor malignancy. Furthermore, sarcoma cell-induced platelet aggregation is dependent on platelet-aggregation inducing factor Aggrus, suggesting that anti-Aggrus neutralizing antibodies would be useful as hematogenous metastasis inhibitors against some types of cancers
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