Toxicological Research in Africa; The risk assessment that paid attention to drug metabolism species specificity

• Project/Area Number: 23710038
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental impact assessment/Environmental policy
• Research Institution: Hokkaido University
• Principal Investigator: IKENAKA Yoshinori 北海道大学, 大学院・獣医学研究科, 講師 (40543509)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 生態系影響評価 / 異物代謝系 / 環境汚染 / 第II相抱合反応 / シトクロムP450 / 種差 / Pyrene / 化学物質感受性 / アフリカ諸国

Research Abstract

We paid attention to a drug metabolism phase II conjugation reaction and determined species specificity of pro-drug metabolism for the wild animal. Sulfate conjugation of pyrene was detected in the pigs which had been thought to have low sulfate conjugation activity by the screening using 11 kinds of mammalian urine. Also, as a result of kinetics analysis, it was found that the enzyme efficiency of the pig was higher than a rat. Whereas, in the investigation carried out in Africa, we obtained amphibians, mammals, avian urine and an organ. As a result of having performed chemical analysis mainly on heavy metal and pesticides, an extremely highly-concentrated chemical was detected in some areas, and the tendency that accumulated a chemical at the level that was higherthan other organism species in birds particularly was observed.

Research Products

• [Journal Article] Organochlorine pesticides and heavy metals in fish from Lake Awassa; Ethiopia: Insights from stable isotope analysis. (2013)
  • Author(s): Yared BY, Ikenaka Y, Nakayama SMM, Saengtienchai A, Watanabe K, Ishizuka M
  • Journal Title: Chemosphere Volume: 91 Pages: 857-863
  • NAID: 120005295656
  • Peer Reviewed
• [Journal Article] Accumulation and biological effects of metals in wild rats in mining areas of Zambia. (2013)
  • Author(s): Nakayama SMM, Ikenaka Y, Hamada K, Muzandu K, Choongo K, Yabe J, Umemura T, Ishizuka M.
  • Journal Title: Environmental Monitoring and Assessment Volume: 185 Pages: 4907-4918
  • Peer Reviewed
• [Journal Article] Metal distribution in tissues of free-range chickens near a lead-zinc mine in Kabwe, Zambia (2013)
  • Author(s): Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Choongo K, Mainda G, Kabeta N, Ishizuka M, Umemura T.
  • Journal Title: Environ Toxicol Chem Volume: 32(1) Pages: 189-92
  • Peer Reviewed
• [Journal Article] GIS-based source estimation of Cu pollution in Lake Itezhi-tezhi and metal accumulation profiles in Oreochromis spp. from both field and laboratory studies. (2013)
  • Author(s): Shigeho Ijiri, Masao Minagawa, Takashi Umemura, Mayumi Ishizuka.
  • Journal Title: Arch Environ Contam Toxicol Volume: 64(1) Pages: 119-29
  • Peer Reviewed
• [Journal Article] Molecular evaluation of a new highly sensitive aryl hydrocarbon receptor in ostriches. (2013)
  • Author(s): Fujisawa N, Darwish WS , Ikenaka Y, Kim E, Lee J,Iwata H, Nakayama SMM, Ishizuka M.
  • Journal Title: Poultry Science Volume: in press
  • Peer Reviewed
• [Journal Article] Accumulation and biological effects of metals in wild rats in mining areas of Zambia. (2013)
  • Author(s): Nakayama SMM, Ikenaka Y, Hamada K, Muzandu K, Choongo K, Yabe J, Umemura T, Ishizuka M
  • Journal Title: Environmental Monitoring and Assessment Volume: in press Issue: 6 Pages: 4907-4918
  • DOI: 10.1007/s10661-012-2912-6
  • Peer Reviewed
• [Journal Article] A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats. (2013)
  • Author(s): Tanaka KD, Kawai YK, Ikenaka Y, Harunari T, Tanikawa T, Fujita S, Ishizuka M
  • Journal Title: J Vet Med Sci. Volume: in press
  • NAID: 40019597159
  • Peer Reviewed
• [Journal Article] Metal distribution in tissues of free-range chickens near a lead-zinc mine in Kabwe, Zambia (2013)
  • Author(s): Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Choongo K, Mainda G, Kabeta N, Ishizuka M, Umemura T
  • Journal Title: Environ Toxicol Chem. Volume: 32 Issue: 1 Pages: 189-92
  • DOI: 10.1002/etc.2029
  • Peer Reviewed
• [Journal Article] GIS-based source estimation of Cu pollution in Lake Itezhi-tezhi and metal accumulation profiles in Oreochromis spp. from both field and laboratory studies. (2013)
  • Author(s): Shouta M.M. Nakayama*, Yoshinori Ikenaka*, Kaampwe Muzandu, Kennedy Choongo, John Yabe, Taro Muroya, Shigeho Ijiri, Masao Minagawa, Takashi Umemura, Mayumi Ishizuka.
  • Journal Title: Arch Environ Contam Toxicol. Volume: 64 Issue: 1 Pages: 119-29
  • DOI: 10.1007/s00244-012-9802-3
  • Peer Reviewed
• [Journal Article] Effects of polycyclic aromatic hydrocarbons (PAHs) on an aquatic ecosystem: acute toxicity and community-level toxic impact tests of benzo[a]pyrene using lake zooplankton community. (2013)
  • Author(s): Yoshinori Ikenaka, Masaki Sakamoto, Takamaru Nagata, Hirokazu Takahashi, Yuichi Miyabara, Takayuki Hanaato, Mayumi Ishizuka, Tomohiro Isobe, Jun-Woo Kim, Kwang-Hyeon Chang.
  • Journal Title: J. Toxicol. Sci. Volume: 38 Pages: 131-6
  • NAID: 10031138734
  • Peer Reviewed
• [Journal Article] Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts (2012)
  • Author(s): Dominic MUREITHI, Wageh Sobhy DARWISH, Yoshinori IKENAKA, Laetitia KANJA, Mayumi ISHIZUKA.
  • Journal Title: Jpn. J.Vet. Res Volume: Nov;60(4) Pages: 205-10
  • NAID: 120005008268
  • Peer Reviewed
• [Journal Article] Accumulation of metals in the liver and kidneys of cattle from agricultural areas in Lusaka (2012)
  • Author(s): Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Ishizuka M, Umemura T
  • Journal Title: Zambia. J Vet Med Sci Volume: 74(10) Pages: 1345-7
  • Peer Reviewed
• [Journal Article] The nucleotide sequence of metallothioneins (MT) in liver of the Kafue lechwe (Kobus leche kafuensis) and their potential as biomarkers of heavy metal pollution of the Kafue River. (2012)
  • Author(s): M'kandawire E, Syakalima M, Muzandu K, Pandey G, Simuunza M, Nakayama SM, Kawai YK, Ikenaka Y, Ishizuka M.
  • Journal Title: Gene Volume: 15;506(2) Pages: 310-6
  • Peer Reviewed
• [Journal Article] Effects of environmental lead contamination on cattle in a lead/zinc mining area: changes in cattle immune systems on exposure to lead in vivo and in vitro. (2012)
  • Author(s): Ikenaka Y, Nakayama SMM, Muroya T, Yabe J, Konnai S, Darwish WS, Muzandu K, Choongo K, Mainda G, Teraoka H, Umemura T, Ishizuka M.
  • Journal Title: Environ Toxicol Chem Volume: 31(10) Pages: 2300-5
  • Peer Reviewed
• [Journal Article] Transcriptional profiling of inflammatory cytokine genes in African buffaloes (Syncerus caffer) infected with Theileria parva (2012)
  • Author(s): Okagawa T, Konnai S, Mekata H, Githaka N, Suzuki S, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K.
  • Journal Title: Vet Immunol Immunopathol Volume: 148(3-4) Pages: 373-9
  • Peer Reviewed
• [Journal Article] Metal and metalloid levels and bio-accumulation characteristics in soil, sediment, land plants and hippopotami (Hippopotamus amphibius L) from the South Luangwa National Park, Zambia. (2012)
  • Author(s): Nakayama SM, Ikenaka Y, Muzandu K, Choongo K, M'kandawire E, Yasuda J,Ishizuka M.
  • Journal Title: Ecotoxicol Environ Saf. Volume: 80 Pages: 333-8
  • NAID: 120005946615
  • Peer Reviewed
• [Journal Article] Organochlorine pesticides and heavy metals in fish from Lake Awassa, Ethiopia : Insights from stable isotope analysis (2012)
  • Author(s): Yared Beyene YOHANNES, et al.
  • Journal Title: Chemosphere Volume: 91 Issue: 6 Pages: 857-863
  • DOI: 10.1016/j.chemosphere.2013.01.047
  • Peer Reviewed
• [Journal Article] Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts. (2012)
  • Author(s): Dominic MUREITHI, Wageh Sobhy DARWISH, Yoshinori IKENAKA, Laetitia KANJA, Mayumi ISHIZUKA.
  • Journal Title: Jpn. J. Vet. Res. Volume: 60 Pages: 205-10
  • NAID: 120005008268
  • Peer Reviewed
• [Journal Article] Accumulation of metals in the liver and kidneys of cattle from agricultural areas in Lusaka, Zambia. (2012)
  • Author(s): Yabe J, Nakayama SMM, Ikenaka Y, Muzandu K, Ishizuka M, Umemura T.
  • Journal Title: J Vet Med Sci. Volume: 74 Pages: 1345-7
  • NAID: 130001879835
  • Peer Reviewed
• [Journal Article] The nucleotide sequence of metallothioneins (MT) in liver of the Kafue lechwe (Kobus leche kafuensis) and their potential as biomarkers of heavy metal pollution of the Kafue River. (2012)
  • Author(s): M’kandawire E, Syakalima M, Muzandu K, Pandey G, Simuunza M, Nakayama SM, Kawai YK, Ikenaka Y, Ishizuka M.
  • Journal Title: Gene Volume: 506 Issue: 2 Pages: 310-6
  • DOI: 10.1016/j.gene.2012.07.002
  • Peer Reviewed
• [Journal Article] Effects of environmental lead contamination on cattle in a lead/zinc mining area : changes in cattle immune systems on exposure to lead in vivo and in vitro. (2012)
  • Author(s): Ikenaka Y, Nakayama SMM, Muroya T, Yabe J, Konnai S, Darwish WS, Muzandu K, Choongo K, Mainda G, Teraoka H, Umemura T, Ishizuka M.
  • Journal Title: Environ Toxicol Chem. Volume: 31 Issue: 10 Pages: 2300-2305
  • DOI: 10.1002/etc.1951
  • Peer Reviewed
• [Journal Article] Transcriptional profiling of inflammatory cytokine genes in Theileria parva-infected African buffalo (Syncerus caffer). (2012)
  • Author(s): Okagawa, T., Konnai, S., Mekata, H., Githaka, N., Suzuki, S., Kariuki, E., Gakuya, F., Kanduma, E., Shirai, T., Ikebuchi, R., Ikenaka, Y., Ishizuka, M., Murata, S., Ohashi.
  • Journal Title: Vet Immunol Immunopathol. Volume: 148 Issue: 3-4 Pages: 373-9
  • DOI: 10.1016/j.vetimm.2012.06.015
  • Peer Reviewed
• [Journal Article] The genetic mechanisms of warfarin resistance in Rattus rattus found in the wild in Japan. (2012)
  • Author(s): Tanaka KD, Kawai Y, Ikenaka Y, Harunari T, Tanikawa T, Ando S, Min HW, Okajima F, Fujita S, Ishizuka M.
  • Journal Title: Pestic Biochem Physiol. Volume: 103 Pages: 144-151
  • NAID: 120004405517
  • Peer Reviewed
• [Journal Article] Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer). (2012)
  • Author(s): Suzuki S, Konnai S, Okagawa T, Githaka NW, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K.
  • Journal Title: Int J Immunogenet Volume: 39 Pages: 170-82
  • Peer Reviewed
• [Journal Article] Molecular Evidence Predicts Aryl Hydrocarbon Receptor Ligand Insensitivity in the Peregrine Falcon (Falco peregrines). (2012)
  • Author(s): Fujisawa N, Ikenaka Y, Kim EY, Lee JS, Iwata H, Ishizuka M.
  • Journal Title: Eur. J. Wildlife. Res. Volume: 58 Pages: 167-175
  • NAID: 120005183149
  • Peer Reviewed
• [Journal Article] Metal and metalloid levels and bio-accumulation characteristics in soil, sediment, land plants and hippopotami (Hippopotamus amphibius L) from the South Luangwa National Park, Zambia. (2012)
  • Author(s): Nakayama SM, Ikenaka Y, Muzandu K, Choongo K, M'kandawire E, Yasuda J, Ishizuka M.
  • Journal Title: Ecotoxicol. Environ. Safe. Volume: 印刷中
  • NAID: 120005946615
  • Peer Reviewed
• [Journal Article] 野生動物の化学物質感受性と生体防御機構 (2011)
  • Author(s): 池中良徳、石塚真由美
  • Journal Title: 安全工学 Volume: 50(2) Pages: 80-80
  • NAID: 10027968452
  • Peer Reviewed
• [Journal Article] Phase-II conjugation ability for PAH metabolism in amphibians: Characteristics and inter-species differences (2011)
  • Author(s): Ueda H, Ikenaka Y, Nakayama SM, Tanaka-Ueno T, Ishizuka M
  • Journal Title: Aquat Toxicol Volume: 105(3-4) Pages: 337-343
  • NAID: 120003762598
  • Peer Reviewed
• [Journal Article] Metal and metalloid contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, Zambia. (2011)
  • Author(s): Nakayama SMM, Ikenaka Y, Hamada K, Muzandu K, Choongo K, Teraoka H, Mizuno N, Ishizuka M.
  • Journal Title: Environmental Pollution Volume: 159 Pages: 175-18
  • NAID: 120002564662
  • Peer Reviewed
• [Journal Article] Astaxanthin can alter CYP1A-dependent activities via two different mechanisms : Induction of protein expression and inhibition of NADPH P450 reductase dependent electron transfer (2011)
  • Author(s): Ohno, M., Darwish, W.S., Ikenaka, Y., Miki, W., Ishizuka, M
  • Journal Title: Food Chem.Toxicol Volume: 49 Issue: 6 Pages: 1285-1291
  • DOI: 10.1016/j.fct.2011.03.009
  • Peer Reviewed
• [Journal Article] Phase-II conjugation ability for PAH metabolism in amphibians : Characteristics and inter-species differences (2011)
  • Author(s): Ueda, H., Ikenaka, Y., Nakayama, S.M., Tanaka-Ueno, T., Ishizuka, M.
  • Journal Title: Aquat.Toxicol. Volume: 105 Issue: 3-4 Pages: 337-343
  • DOI: 10.1016/j.aquatox.2011.07.004
  • NAID: 120003762598
  • Peer Reviewed
• [Journal Article] Uptake of lead, cadmium, and other metals in the liver and kidneys of cattle near a lead-zinc mine in Kabwe, Zambia (2011)
  • Author(s): Yabe, J., Nakayama, S.M., Ikenaka, Y., Muzandu, K., Ishizuka, M., Umemura, T.
  • Journal Title: Environ.Toxicol.Chem. Volume: 30 Issue: 8 Pages: 1892-1897
  • DOI: 10.1002/etc.580
  • Peer Reviewed
• [Journal Article] Comparative metabolism of warfarin in rats and chickens (2011)
  • Author(s): Aksorn Saengtienchai
  • Journal Title: Poultry Science Volume: 90 Issue: 12 Pages: 2775-2781
  • DOI: 10.3382/ps.2010-01257
  • Peer Reviewed
• [Journal Article] Occurrence, distribution and ecological risk assessment of DDTs and heavy metals in surface sediments from Lake Awassa -Ethiopian Rift Valley Lake
  • Author(s): B, Ikenaka Y, Saengtienchai A, Watanabe KP,Nakamyama SMM, Ishizuka M.
  • Journal Title: Pollut Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer).
  • Author(s): Suzuki S, Konnai S, Okagawa T, Githaka NW, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K.
  • Journal Title: Int J Immunogenet. 2012 Apr Volume: 39(2) Pages: 170-82
  • Peer Reviewed
• [Journal Article] Uptake of lead, cadmium, and other metals in the liver and kidneys of cattle near a lead-zinc mine in Kabwe, Zambia.
  • Author(s): Yabe J, Nakayama SM, Ikenaka Y, Muzandu K, Ishizuka M, Umemura T.
  • Journal Title: Environ Toxicol Chem. 2011 Aug Volume: 30(8) Pages: 1892-7
  • Peer Reviewed
• [Presentation] Effect of mining activity on wild and domestic animals: Case study of lead ? zink mining area,Kabwe, Zambia (2013)
  • Author(s): Yoshinori Ikenaka
  • Organizer: 日本学術会議北海道地区会議主催学術講演会
  • Place of Presentation: 北海道大学学術交流会館小講堂
  • Year and Date: 2013-03-01
• [Presentation] Effect of mining activity on wild and domestic animals: Case study of lead – zink mining area, Kabwe, Zambia (2013)
  • Author(s): 池中良徳
  • Organizer: 日本学術会議北海道地区会議主催学術講演会
  • Place of Presentation: 北海道大学学術交流会館小講堂
  • Invited
• [Presentation] ワルファリン抵抗性メカニズム (2013)
  • Author(s): 池中良徳
  • Organizer: 第155回 日本獣医学会学術集会
  • Place of Presentation: 東京大学駒場キャンパス
  • Invited
• [Presentation] Characteristics of phase II metabolism reaction in pig: Clear sulfation and sulfotransferase activity observed in pyrene (2013)
  • Author(s): アクソルン・サエンティエンチャイ
  • Organizer: The 155th Meeting of the Japanese Society of Veterinary Science
  • Place of Presentation: Tokyo University, Komaba, Japan
• [Presentation] 海鳥における金属の汚染状況と蓄積特性の解析 (2013)
  • Author(s): 石井千尋
  • Organizer: 第155回 日本獣医学会学術集会
  • Place of Presentation: 東京大学駒場キャンパス
• [Presentation] 両生類の異物代謝機構の特徴と種差 (2012)
  • Author(s): 池中良徳
  • Organizer: 第21回環境化学討論会
  • Place of Presentation: 愛媛県県民文化会館(ひめぎんホール)
• [Presentation] 鳥類における薬物代謝の特徴:ピレンをモデル化合物として (2012)
  • Author(s): 池中良徳
  • Organizer: 第21回環境化学討論会
  • Place of Presentation: 愛媛県県民文化会館(ひめぎんホール)
• [Presentation] 薬物代謝第II 相抱合反応の種差:多環芳香族炭化水素の抱合反応と哺乳動物で観察された種差 (2012)
  • Author(s): 池中良徳
  • Organizer: 第21回環境化学討論会
  • Place of Presentation: 愛媛県県民文化会館(ひめぎんホール)
• [Presentation] 鳥類における薬物代謝の特徴：ピレンをモデル化合物として (2012)
  • Author(s): 池中良徳
  • Organizer: 第21回環境化学討論会
  • Place of Presentation: 愛媛県県民文化会館（ひめぎんホール）
• [Presentation] 薬物代謝第II相抱合反応の種差：多環芳香族炭化水素の抱合反応と哺乳動物で観察された種差 (2012)
  • Author(s): 池中良徳
  • Organizer: 第21回環境化学討論会
  • Place of Presentation: 愛媛県県民文化会館（ひめぎんホール）
• [Presentation] 両生類の異物代謝機構の特徴と種差 (2012)
  • Author(s): 池中良徳
  • Organizer: 第21回環境化学討論会
  • Place of Presentation: 愛媛県県民文化会館（ひめぎんホール）
• [Presentation] Metal contaminated soil from mining area caused metal accumulation and biological responses in rats －from field and laboratory studies－ (2012)
  • Author(s): 中山翔太
  • Organizer: 4th International Toxicology Symposium in Africa
  • Place of Presentation: The University of Zambia, Lusaka, Zambia
  • Invited
• [Presentation] Metal contaminated soil from mining area caused accumulation and biological responses in rats －from field and laboratory studies－ (2012)
  • Author(s): 中山翔太
  • Organizer: SETAC Asia/Pacific Annual Meeting 2012
  • Place of Presentation: ANA New Sky Hotel Kumamoto
• [Presentation] Cross-talks between heavy metals and xenobiotics metabolizing enzymes (2012)
  • Author(s): ワギ ソベイ
  • Organizer: The 39th annual meeting of the Japanese Society of Toxicology
  • Place of Presentation: Sendai International center, Sendai, Japan
• [Presentation] Predicting toxicological effects on Ostrich using high-throughput sequencing data (2012)
  • Author(s): 川合佑典
  • Organizer: SETAC Asia Pacific 2012
  • Place of Presentation: ANA Hotel Kumamoto New Sky, Kumamoto, Japan
• [Presentation] ダチョウ肝臓に発現する異物代謝酵素の配列解析 (2012)
  • Author(s): 川合佑典
  • Organizer: 日本進化学会
  • Place of Presentation: 首都大学東京南大沢キャンパス
• [Presentation] 脊椎動物における異物代謝酵素の分子進化 (2012)
  • Author(s): 川合佑典
  • Organizer: 2012年度P450とUGT/SULT勉強会
  • Place of Presentation: 関西学院大学神戸三田キャンパス
• [Presentation] The study of polycyclic aromatic hydrocarbons (PAHs) and its metabolite as a biomarker for PAH exposures in wildlife animals (2012)
  • Author(s): アクソルン・サエンティエンチャイ
  • Organizer: 39th Annual Meeting of the Japanese Society of Japan
  • Place of Presentation: Akira naganuma, Tohoku University, Sendai, Japan
• [Presentation] Interspecies difference of phase II reaction in mammals; determination of pyrene metabolites from the urine of various mammalian species (2012)
  • Author(s): アクソルン・サエンティエンチャイ
  • Organizer: SETAC Asia Pacific 2012
  • Place of Presentation: ANA Hotel Kumamoto New Sky, Kumamoto, Japan
• [Presentation] Analysis of Chicken CYP1-4: mRNA Expressions and Genomic Analysis (2012)
  • Author(s): 渡邉研右
  • Organizer: 11th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
  • Place of Presentation: Torino, Italy
• [Presentation] 鳥類異物代謝における重要なCYP分子種の特定とその種差の解明 (2012)
  • Author(s): 渡邉研右
  • Organizer: 第39回日本毒性学会学術年会
  • Place of Presentation: 宮城県仙台国際センター
• [Presentation] The identification of the important CYP isoforms in avian xenobiotics metabolism and its species difference among bird species (2012)
  • Author(s): 渡邉研右
  • Organizer: The 6th International Congress of Asian Society of Toxicology
  • Place of Presentation: Sendai International Center, Miyagi
• [Presentation] Levels and Bioaccumulation of Organochlorine Pesticides in Fish Species from Lake Ziway, ETHIOPIA (2012)
  • Author(s): ヤレド・ベイェネ
  • Organizer: 21th symposium on Environmental Chemistry
  • Place of Presentation: Matsuyama, Ehime
• [Presentation] Bioaccumulation levels of organochlorine pesticides in fish species from Ethiopian Rift Valley Lake Ziway, Ethiopia (2012)
  • Author(s): ヤレド・ベイェネ
  • Organizer: SETAC AP; 2012
  • Place of Presentation: ANA New Sky Hotel Kumamoto
• [Presentation] Metabolism of pyrene, a polycyclic aromatic hydrocarbon in freshwater turtles (2012)
  • Author(s): オロスラーニュ・バラージュ
  • Organizer: 4th International Toxicology Symposium in Africa
  • Place of Presentation: The University of Zambia, Lusaka, Zambia
  • Invited
• [Presentation] 魚類における異物代謝機構の特徴と種差：多環芳香族炭化水素（ＰＡＨ）に対する生体防御 (2012)
  • Author(s): 小栗真美
  • Organizer: 第21回環境化学討論会
  • Place of Presentation: 愛媛県県民文化会館（ひめぎんホール）
• [Presentation] 鳥類における薬物代謝の特徴：ピレンをモデル化合物として (2012)
  • Author(s): 河田みなみ
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学（岩手県盛岡市）
• [Presentation] Heavy metal pollution in sea birds (2012)
  • Author(s): 石井千尋
  • Organizer: 4th International Toxicology Symposium in Africa
  • Place of Presentation: The University of Zambia, Lusaka, Zambia
• [Presentation] In vitro diazepam metabolism in horses (2012)
  • Author(s): 速水秋
  • Organizer: 4th International Toxicology Symposium in Africa
  • Place of Presentation: The University of Zambia, Lusaka, Zambia
• [Presentation] 鳥類における第I相および第II相反応の特徴と種差 (2012)
  • Author(s): 河田みなみ 池中良徳 渡邉研右 アクソルン・サエンティエンチャイ 大野円実 石塚真由美
  • Organizer: 第153回日本獣医学会
  • Place of Presentation: 大宮ソニックシティー(大宮市)
• [Presentation] Field toxicological research activity in African countries (2012)
  • Author(s): Yoshinori IKENAKA
  • Organizer: Environmental Pollution and food safety in Africa(招待講演)
  • Place of Presentation: Hokkaido University, Sapporo, Japan
• [Presentation] Species diversity in phase II reaction in polycyclic aromatic hydrocarbons (PAHs) (2011)
  • Author(s): Aksorn Saengtienchai, Yohinori Ikenaka, Michito Shimozuru, Mariko Sajika, Toshio Tsubota, Amnart Poapolathep, Mayumi Ishizuka
  • Organizer: The 14th Seoul National University ‐ Hokkaido University Joint Symposium 21st Century Advances in Veterinary Medical Sciences
  • Place of Presentation: College of Veterinary Medicine, Seoul National University, Seoul, Korea
• [Presentation] The environmental pollution in Zambia: Effects of current mining activities on domestic animals and wild life. (2011)
  • Author(s): Yoshinori Ikenaka, Shouta Nakayama, Kaampwe Muzandu, Kennedy Choongo, Hiroki Teraoka, Mayumi Ishizuka
  • Organizer: The 14th Seoul National University - Hokkaido University Joint Symposium 21st Century Advances in Veterinary Medical Sciences(招待講演)
  • Place of Presentation: College of Veterinary Medicine, Seoul National University, Seoul, Korea
• [Presentation] GIS based source estimation of Cu pollution in Lake Itezhi-tezhi and Cu accumulation profile in Oreochromis sp. from the field and laboratory studies (2011)
  • Author(s): Shouta M.M. Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, John Yabe, Taro Muroya, Shigeho Ijiri, Takashi Umemura, Mayumi Ishizuka
  • Organizer: SETAC North America 32nd Annual Meeting
  • Place of Presentation: Hynes Convention Center (Boston, USA)
• [Presentation] 汚染環境下の野生動物の適応と毒性 (2011)
  • Author(s): 石塚真由美、池中良徳
  • Organizer: フォーラム2011・衛生薬学環境トキシコロジーシンポジウム(招待講演)
  • Place of Presentation: 金沢エクセルホテル東急（金沢）
• [Presentation] アカハライモリとアフリカツメガエルにおける異物代謝酵素の比較 (2011)
  • Author(s): 上田春樹、中山翔太、川合佑典、田中-上野寛子、池中良徳・石塚真由美
  • Organizer: 日本爬虫両棲類学会 第50回大会
  • Place of Presentation: 京都大学北部構内 理学部（京都）
• [Presentation] Effects of current malaria control in lake environment; The levels of Organochlorine pesticide and toxic metals in fish species from Lake Awassa, Ethiopia (2011)
  • Author(s): Yoshinori IKENAKA, Yared Beyene, Kensuke WATANABE, Aksorn Saengtienchai, Shouta NAKAYAMA, Mayumi ISHIZUKA
  • Organizer: 3rd International Toxicology Symposium in Africa(招待講演)
  • Place of Presentation: University of Zambia (Lusaka, Zambia)
• [Presentation] GIS-based source estimation of Cu pollution in Lake Itezhi-tezhi and metal accumulation profiles in Oreochromis sp. and other fish species from both and laboratory studies (2011)
  • Author(s): Shouta M.M. Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, John Yabe, Taro Muroya, Shigeho Ijiri, Takashi Umemura, Mayumi Ishizuka
  • Organizer: 3rd International Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia (Lusaka, Zambia)
• [Presentation] Metal concentration and stable isotope ratio analysis (d13C and d15N) in water, sediment and fish from Lake Itezhi-tezhi, Zambia (2011)
  • Author(s): Shouta M.M. Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, John Yabe, Taro Muroya, Takashi Umemura, Mayumi Ishizuka
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学（熊本）
• [Presentation] Metal and metalloid levels and bio-accumulation characteristics in soil, sediment, land plants and hippopotami (Hippopotamus amphibius L) from the South Luangwa National Park, Zambia (2011)
  • Author(s): Shouta M.M. Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, Ethel M’kandawire, Jun Yasuda, Mayumi Ishizuka
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学（熊本）
• [Presentation] Effects of current malaria control in lake environment; The levels of Organochlorine pesticide and toxic metals in fish species from Lake Awassa, ETHIOPIA (2011)
  • Author(s): YARED Beyene, Yoshinori IKENAKA, Kensuke WATANABE, Aksorn SAENGTIENCHAI, Shouta NAKAYAMA, Mayumi ISHIZUKA
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学（熊本）
• [Presentation] ガーナの金鉱山周辺（オブアシ自治区）における金属汚染と野生ラットにおける毒性影響評価 (2011)
  • Author(s): 大谷豪，池中良徳，中山翔太，Osei Akoto，Joseph APAU，Elvis BAIDOO,石塚真由美
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学（熊本）
• [Presentation] Species diversity in phase II reaction of pyrene metabolism (2011)
  • Author(s): SAENGTIENCHAI, Yoshinori IKENAKA, Mayumi ISHIZUKA
  • Organizer: 第38回日本トキシコロジー学会
  • Place of Presentation: Attractive Convention Complex, Pacifico Yokohama, Japan
• [Presentation] 多環芳香族炭化水素類(PAHs)に対する魚類の異物代謝機構の解明：魚類で観察された第II相抱合反応の特徴と種差 (2011)
  • Author(s): 小栗真美 池中良徳 Aksorn Saengtienchai 上田春樹 石塚真由美
  • Organizer: 第38回日本トキシコロジー学会
  • Place of Presentation: Attractive Convention Complex, Pacifico Yokohama, Japan
• [Presentation] Metal concentration and stable isotope ratio analysis (d13C and d15N) in water, sediment and fish from Lake Itezhi-tezhi, Zambia (2011)
  • Author(s): Shouta M.M. Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, Jun Yasuda, Mayumi Ishizuka
  • Organizer: 3rd CSTS and 5th SETAC- Africa Joint Toxicology Conference
  • Place of Presentation: University of Buea (Buea, Cameroon)
• [Presentation] Concentration and bioaccumulation of 10 metals in soil, river sediment, plant and hippopotamus (Hippopotamus amphibius L) in the South Luangwa National Park, Zambia (2011)
  • Author(s): Shouta M.M. Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, Jun Yasuda, Mayumi Ishizuka
  • Organizer: 3rd CSTS and 5th SETAC- Africa Joint Toxicology Conference
  • Place of Presentation: University of Buea (Buea, Cameroon)
• [Book] 獣医学・応用動物科学系学生のための野生動物学 (2013)
  • Author(s): 村田浩一 坪田敏男
  • Publisher: 野生動物と環境汚染
• [Book] 獣医学・応用動物科学系学生のための野生動物学 (2013)
  • Author(s): 村田浩一
  • Total Pages: 341
  • Publisher: 文英堂出版
• [Remarks] 北海道大学アフリカ研究会
  • URL: http://aa.vetmed.hokudai.ac.jp/africa/
• [Remarks] 北海道大学大学院獣医学研究科毒性学教室
  • URL: http://tox.vetmed.hokudai.ac.jp/