Toxicological Research in Africa; The risk assessment that paid attention to drug metabolism species specificity
| Project/Area Number |
23710038
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 生態系影響評価 / 異物代謝系 / 環境汚染 / 第II相抱合反応 / シトクロムP450 / 種差 / Pyrene / 化学物質感受性 / アフリカ諸国 |
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| Research Abstract |
We paid attention to a drug metabolism phase II conjugation reaction and determined species specificity of pro-drug metabolism for the wild animal. Sulfate conjugation of pyrene was detected in the pigs which had been thought to have low sulfate conjugation activity by the screening using 11 kinds of mammalian urine. Also, as a result of kinetics analysis, it was found that the enzyme efficiency of the pig was higher than a rat. Whereas, in the investigation carried out in Africa, we obtained amphibians, mammals, avian urine and an organ. As a result of having performed chemical analysis mainly on heavy metal and pesticides, an extremely highly-concentrated chemical was detected in some areas, and the tendency that accumulated a chemical at the level that was higherthan other organism species in birds particularly was observed.
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Report
(3 results)
Research Products
(86 results)
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[Journal Article] Effects of environmental lead contamination on cattle in a lead/zinc mining area: changes in cattle immune systems on exposure to lead in vivo and in vitro.2012
Author(s)
Ikenaka Y, Nakayama SMM, Muroya T, Yabe J, Konnai S, Darwish WS, Muzandu K, Choongo K, Mainda G, Teraoka H, Umemura T, Ishizuka M.
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Journal Title
Environ Toxicol Chem
Volume: 31(10)
Pages: 2300-5
Related Report
Peer Reviewed
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[Journal Article] Transcriptional profiling of inflammatory cytokine genes in African buffaloes (Syncerus caffer) infected with Theileria parva2012
Author(s)
Okagawa T, Konnai S, Mekata H, Githaka N, Suzuki S, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K.
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Journal Title
Vet Immunol Immunopathol
Volume: 148(3-4)
Pages: 373-9
Related Report
Peer Reviewed
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[Journal Article] Effects of environmental lead contamination on cattle in a lead/zinc mining area : changes in cattle immune systems on exposure to lead in vivo and in vitro.2012
Author(s)
Ikenaka Y, Nakayama SMM, Muroya T, Yabe J, Konnai S, Darwish WS, Muzandu K, Choongo K, Mainda G, Teraoka H, Umemura T, Ishizuka M.
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Journal Title
Environ Toxicol Chem.
Volume: 31
Issue: 10
Pages: 2300-2305
DOI
Related Report
Peer Reviewed
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[Journal Article] Transcriptional profiling of inflammatory cytokine genes in Theileria parva-infected African buffalo (Syncerus caffer).2012
Author(s)
Okagawa, T., Konnai, S., Mekata, H., Githaka, N., Suzuki, S., Kariuki, E., Gakuya, F., Kanduma, E., Shirai, T., Ikebuchi, R., Ikenaka, Y., Ishizuka, M., Murata, S., Ohashi.
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Journal Title
Vet Immunol Immunopathol.
Volume: 148
Issue: 3-4
Pages: 373-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer).2012
Author(s)
Suzuki S, Konnai S, Okagawa T, Githaka NW, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K.
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Journal Title
Int J Immunogenet
Volume: 39
Pages: 170-82
Related Report
Peer Reviewed
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[Journal Article] Uptake of lead, cadmium, and other metals in the liver and kidneys of cattle near a lead-zinc mine in Kabwe, Zambia2011
Author(s)
Yabe, J., Nakayama, S.M., Ikenaka, Y., Muzandu, K., Ishizuka, M., Umemura, T.
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Journal Title
Environ.Toxicol.Chem.
Volume: 30
Issue: 8
Pages: 1892-1897
DOI
Related Report
Peer Reviewed
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[Journal Article] Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer).
Author(s)
Suzuki S, Konnai S, Okagawa T, Githaka NW, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K.
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Journal Title
Int J Immunogenet. 2012 Apr
Volume: 39(2)
Pages: 170-82
Related Report
Peer Reviewed
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