Elucidation of insecticide detoxification by hydrolases and evaluation of species difference between humans and experimental animals
| Project/Area Number |
23710042
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | Ehime University |
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Principal Investigator |
NISHI Kosuke 愛媛大学, 農学部, 助教 (80578097)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 健康影響評価 / エステラーゼ / 殺虫剤 / ピレスロイド / 加水分解 / 種差 |
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| Research Abstract |
A library of recombinant hydrolases expressed in human liver was generated using the baculovirus expression system. When the library was screened with pyrethroids and their derivatives containing a fluorochrome, novel enzymes that hydrolyze the insecticides were discovered. Biochemical characteristics of the enzymes was analyzed.
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Report
(3 results)
Research Products
(63 results)
