| Project/Area Number |
23710046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | Oita University of Nursing and Health Sciences |
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Principal Investigator |
HE Miao 大分県立看護科学大学, 看護学部, 研究員 (70600675)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | スギ花粉症 / β-グルカン / 黄砂 / アレルギー性鼻炎 / マウス / Cryj1 / ベルカンデラ / 好酸球 / βーグルカン / ビルカンデラ |
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| Research Abstract |
Epidemiologic studies have shown that Asian sand dust (ASD) events coincided with an increase in child and adult asthma and allergic rhinitis including Japanese cedar pollinosis.The wind-borne ASD contains various microbial agents, such as bacteria, fungi, fungal spores, and viruses. However, it is unclear the effects of microbial materials like β-glucan derived from fungi on Japanese cedar pollinosis.Recently Bjerkandera adusta, which is a fungus, was isolated from ASD aerosol. In this study,the exacerbating effects of the fungus, Bjerkandera (Bjer) and heated (H)-ASD on Japanese cedar pollen (Cryj1)-induced allergic rhinitis were investigated in BAL/c female mice. Bjer, itself caused allergic rhinitis. The Cryj1-induced allergic rhinitis was enhanced by co-exposure of Bjer+H-ASD.These results suggest that β-glucan together with ASD may play an important role in the aggravation of Japanese cedar pollinosis.
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