X-ray induced autophagy in radioresistant cells

• Project/Area Number: 23710066
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Tohoku University
• Principal Investigator: KUWAHARA Yoshikazu 東北大学, 加齢医学研究所, 助教 (00392225)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 放射線耐性 / 活性酸素種 / 臨床的放射線耐性 / ROS / 過酸化水素 / ミトコンドリア

Research Abstract

Efficient removal of reactive oxygen species from cytoplasm of clinically relevant radioresistant cells leads to low incidence of autophagic cell death of those cells after X-ray exposure.

Research Products

• [Journal Article] Distribution of artificial radionuclides in abandoned cattle in theeva cuation zone of the Fukushima Daiichi nuclear power plant (2013)
  • Author(s): Fukuda T, Kino Y, Abe Y, Yamashiro H, Kuwahara Y, Nihei H, Sano Y, Irisawa A, Shimura T, Fukumoto M, Shinoda H, Obata Y, Saigusa S, Sekine T, Isogai E, Fukumoto M.
  • Journal Title: PLoS One Volume: 8(1) Issue: 1 Pages: 1-7
  • DOI: 10.1371/journal.pone.0054312
  • Peer Reviewed
• [Journal Article] Distribution of artificial radionuclides in abandoned cattle in the evacuation zone of the Fukushima Daiichi nuclear power plant. (2013)
  • Author(s): Fukuda T.
  • Journal Title: PLoS One. Volume: 8
  • Peer Reviewed
• [Journal Article] Effect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes (2012)
  • Author(s): Kobayashi T, Saito Y, Ohtake Y, Maruko A, Yamamoto Y, Yamamoto F, Kuwahara Y, Fukumoto M, Fukumoto M, Ohkubo Y.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 3(7) Issue: 7 Pages: G861-G869
  • DOI: 10.1152/ajpgi.00081.2012
  • Peer Reviewed
• [Journal Article] Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells (2012)
  • Author(s): Shimura T, Noma N, Oikawa T, Ochiai Y, Kakuda S, Kuwahara Y, Takai Y, TakahashiA, Fukumoto M.
  • Journal Title: Oncogenesis Volume: 1 Issue: 6 Pages: e12-e12
  • DOI: 10.1038/oncsis.2012.12
  • Peer Reviewed
• [Journal Article] Effect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes. (2012)
  • Author(s): Kobayashi T
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. Volume: 303 Pages: 861-869
  • Peer Reviewed
• [Journal Article] Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells. (2012)
  • Author(s): Shimura T
  • Journal Title: Oncogenesis. Volume: 1
  • Peer Reviewed
• [Journal Article] Adenovirus-mediated expression of the HO-1 protein within MSCs decreased cytotoxicity and inhibited apoptosis induced by oxidative stresses. (2012)
  • Author(s): Hamedi-Asl P, Halabian R, Bahmani P, Mohammadipour M, Mohammadzadeh M, Roushandeh AM, Jahanian-Najafabadi A, Kuwahara Y, Roudkenar MH.
  • Journal Title: Cell Stress Chaperones. Volume: 17 Pages: 181-190
  • Peer Reviewed
• [Journal Article] Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy (2011)
  • Author(s): Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar, M Fukumoto, T Shimura, Y Ohtake M H, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M
  • Journal Title: Cell Death Dis (2011) Volume: 2 Issue: 6 Pages: e177-e177
  • DOI: 10.1038/cddis.2011.56
  • Peer Reviewed
• [Journal Article] Neutrophil gelatinase-associated lipocalin: a new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1. (2011)
  • Author(s): Roudkenar MH, Halabian R, Bahmani P, Roushandeh AM, Kuwahara Y, Fukumoto M.
  • Journal Title: Free Radic Res. Volume: 45 Pages: 810-819
  • Peer Reviewed
• [Presentation] 被災家畜における放射性物質の動態及びと畜前推定技術の検証 (2013)
  • Author(s): 山城秀昭、阿部靖之、福田智一、木野康志、桑原義和、福本基、小林仁、篠田壽、関根勉、磯貝恵美子、福本学
  • Organizer: 放射性物質汚染と食の安全-被災地の畜産業復興を願って-
  • Place of Presentation: 東京
  • Year and Date: 2013-03-16
• [Presentation] 臨床的放射線耐性細胞はなぜドセタキセルに耐性を示すのか? (2012)
  • Author(s): 桑原義和、福本基、福本学
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 臨床的放射線耐性細胞がなぜドセタキセルに耐性を示すのか? (2012)
  • Author(s): 桑原義和、福本基、福本学
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 臨床的放射線耐性細胞がなぜドセタキセルに耐性を示すのか? (2012)
  • Author(s): 桑原義和、福本基、福本学
  • Organizer: 日本放射線影響学会第55回大会
  • Place of Presentation: 仙台
• [Presentation] 臨床的放射線耐性細胞はなぜドセタキセルに耐性を示すのか？ (2012)
  • Author(s): 桑原義和
  • Organizer: 第１０１回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 臨床的放射線耐性細胞がなぜドセタキセルに耐性を示すのか？ (2012)
  • Author(s): 桑原義和
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 臨床的放射線耐性細胞がなぜドセタキセルに耐性を示すのか？ (2012)
  • Author(s): 桑原義和
  • Organizer: 日本放射線影響学会第55回大会
  • Place of Presentation: 仙台
• [Presentation] AKT経路を標的としたがん幹細胞の放射線耐性の克服 (2011)
  • Author(s): 志村勉、落合泰史、野間直十、及川利幸、桑原義和、福本学
  • Organizer: 日本放射線影響学会第54回大会
  • Place of Presentation: 神戸
• [Presentation] 臨床的放射線耐性細胞はなぜドセタキセルに耐性を示すのか? (2011)
  • Author(s): 桑原義和、及川利幸、福本基、志村勉、福本学
  • Organizer: 日本放射線影響学会第54回大会
  • Place of Presentation: 神戸
• [Presentation] X線抵抗性細胞の重粒子線感受性について (2011)
  • Author(s): 高橋昭久、吉田由香里、馬洪玉、桑原義和、福本学、金井達明、中野隆史
  • Organizer: 日本放射線影響学会第54回大会
  • Place of Presentation: 神戸
• [Remarks]
  • URL: http://www2.idac.tohoku.ac.jp/dep/path/