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Molecular pathology of hereditary microcephaly by the dysfunction of DNA repair

Research Project

Project/Area Number 23710068
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation/Chemicals
Research InstitutionHiroshima University

Principal Investigator

MIYAMOTO Tatsuo  広島大学, 原爆放射線医科学研究所, 助教 (40452627)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords遺伝性小頭症 / DNA損傷修復欠損症
Research Abstract

Radiation exposure in utero induces severe microcephaly with mental retardation. However, less is known about the molecular and cellular pathology of microcephaly.This study revealed that mutations of the MRE11A gene causes hereditary microcephaly via the aberrant enhancement of ATM-dependent apoptosis. Moreover we demonstrated that the unrelated two patients with Seckel syndrome were compound-heterozygotes of null type mutations of pericentrin gene encoding a centrosome protein, and that G1 phase-arrested population in the patient cells increased by an aberrant activation of p53-p21 pathway. Taken together, these results shed light on the molecular basis of genetic microcephaly.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (71 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 9 results) Presentation (56 results) Remarks (3 results)

  • [Journal Article] TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome.2014

    • Author(s)
      Ochiai H, Miyamoto T, Kanai A, Hosoba K, Sakuma T, Kudo Y, Asami K, Ogawa A, Watanabe A, Kajii T, Yamamoto T, Matsuura S.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111(4) Issue: 4 Pages: 1461-6

    • DOI

      10.1073/pnas.1317008111

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.2013

    • Author(s)
      Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 3379-3379

    • DOI

      10.1038/srep03379

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient TALEN construction and evaluation methods for human cell and animal applications.2013

    • Author(s)
      Sakuma T, Hosoi S, Woltjen K, Suzuki KI, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T.
    • Journal Title

      Genes to Cells

      Volume: (In press) Issue: 4 Pages: 315-326

    • DOI

      10.1111/gtc.12037

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos.2012

    • Author(s)
      Ochiai H, Sakamoto N, Fujita K, Nishikawa M, Suzuki K, Matsuura S, Miyamoto T, Sakuma T, Shibata T, Yamamoto T.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 109 Issue: 27 Pages: 10915-10920

    • DOI

      10.1073/pnas.1202768109

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ゲノム安定性を司る紡錘体チェックポイント因子BUBR1の間期中心体における機能2012

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Journal Title

      長崎医学会雑誌

      Volume: 87 Pages: 235-238

    • URL

      http://ci.nii.ac.jp/naid/110009523696

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 分裂期チェックポイント分子BUBR1欠損による高発がん性と繊毛病2012

    • Author(s)
      宮本達雄、松浦伸也
    • Journal Title

      広島医学

      Volume: 65 Pages: 308-310

    • URL

      http://ci.nii.ac.jp/naid/40019319233

    • Related Report
      2013 Final Research Report
  • [Journal Article] Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates2011

    • Author(s)
      Miyamoto, T., et.al.
    • Journal Title

      Human Molcular Genetics

      Volume: 20 Issue: 10 Pages: 2058-2070

    • DOI

      10.1093/hmg/ddr090

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.2011

    • Author(s)
      松本 祥幸
    • Journal Title

      DNA Repair

      Volume: 10 Issue: 3 Pages: 314-321

    • DOI

      10.1016/j.dnarep.2010.12.002

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging of tight junctions using claudin-EGFP transgenic medaka2011

    • Author(s)
      Miyamoto T, et al
    • Journal Title

      Methods Mol Biol

      Volume: 762 Pages: 171-178

    • DOI

      10.1007/978-1-61779-185-7_12

    • ISBN
      9781617791840, 9781617791857
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.2011

    • Author(s)
      Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Sakemi Y, Matsuura S.
    • Journal Title

      DNA Repair (Amst).

      Volume: 10(3) Pages: 314-321

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates.2011

    • Author(s)
      Miyamoto T, Porazinski S, Wang H, Borovina A, Ciruna B, Shimizu A, Kajii T, Kikuchi A, Furutani-Seiki M, Matsuura S.
    • Journal Title

      Hum Mol Genet.

      Volume: 20(10) Pages: 2058-2070

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging of tight junctions using claudin-EGFP transgenic medaka.2011

    • Author(s)
      Miyamoto T, Furuse M, Furutani-Seiki M.
    • Journal Title

      Methods Mol Biol.

      Volume: 762 Pages: 171-178

    • Related Report
      2011 Research-status Report
  • [Presentation] Individual difference of radiosensitivity detected by cytokinesis-blocked micronucleus assay2014

    • Author(s)
      Royba E, Akutsu SN, Miyamoto T, Matsuura S
    • Organizer
      The 3rd International Sympodium of Phoenix Leader Education Program
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional evaluation of single nucleotide polymorphisms linked to radiosensitivity using genome editing 4th technology2014

    • Author(s)
      Miyamoto T, Ochiai H, Royba E, Matsuura S
    • Organizer
      The International Symposium of RIRBM, Hiroshima University
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional evaluation of single nucleotide polymorphisms linked to radio sensitivity using genomic editing technology2014

    • Author(s)
      Miyamoto T, Ochiai H, Royba E, Matsuura S
    • Organizer
      The 4th International symposium of RIRBM, Hiroshima University
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト培養細胞における一塩基編集技術 : 放射線感受性SNPの定量的評価系確立への試み2013

    • Author(s)
      宮本達雄、落合博、久米悟士、佐久間哲史、山本卓、松浦伸也
    • Organizer
      第38回中国地区放射線影響研究会
    • Place of Presentation
      広島
    • Year and Date
      2013-07-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞増殖に連動した分裂期キネシンKIF2Aによる繊毛退縮機構2013

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      第54回原子爆弾後障害研究会
    • Place of Presentation
      広島
    • Year and Date
      2013-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 分裂期キネシンKIF2Aを介した細胞増殖に共役した繊毛退縮機構2013

    • Author(s)
      宮本達雄、細羽康介、落合博、佐久間哲史、山本卓、松浦伸也
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Identification of an extragenic mutation for PCS(MVA) syndrome and functional analysis using artificial nucleases2013

    • Author(s)
      Miyamoto T, Ochiai H, Kanai A, Hosoba K, Kume S, Sakuma T, Yamamoto T, Matsuura S
    • Organizer
      ASHG 63rd annual meeting
    • Place of Presentation
      Boston U.S.A.
    • Related Report
      2013 Final Research Report
  • [Presentation] 人工ヌクレアーゼを用いたヒト培養細胞での一塩基編集 : 放射線感受性SNPの評価系構築への試み2013

    • Author(s)
      宮本達雄、落合博、金井昭教、久米悟士、佐久間哲史、山本卓、松浦伸也
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      青森
    • Related Report
      2013 Final Research Report
  • [Presentation] Identification of an extragenic mutation for PCS(MVA) syndrome and functional analysis using artificial nucleases2013

    • Author(s)
      松浦伸也、落合博、宮本達雄、金井昭教、細羽康介、久米悟士、佐久間哲史、野地澄晴、山本卓
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] The PLK1-KIF2A pathway in the context of growth signal dependent primary cilia disassembly2013

    • Author(s)
      宮本達雄、細羽康介、落合博、佐久間哲史、山本卓、松浦伸也
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Ciliary disassembly by the enhanced PLK1-KIF2A pathway in a spindle assembly checkpoint-deficiency syndrome2013

    • Author(s)
      Miyamoto T, Hosoba K, Ochiai H, Sakuma T, Yamamoto T, Matsuura S
    • Organizer
      The 25th CDB meeting
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Artificial nuclease-based targeted DSB introduction and its application2013

    • Author(s)
      Ochiai H, Miyamoto T, Kanai A, Hosoba K, Sakuma T, Yamamoto T, Matsuura S
    • Organizer
      The 3th International Symposium of RIRBM, Hiroshima University
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] KIF2A phosphorylation by PLK1 regulates primary cilia diassembly2013

    • Author(s)
      Hosoba K, Miyamoto T, Ochiai H, Matsuura S
    • Organizer
      The 2nd International Sympodium of Phoenix Leader Education Program
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト分裂期チェックポイント欠損症における繊毛形成異常2013

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      2013年生体運動合同班会議
    • Place of Presentation
      東広島
    • Related Report
      2013 Final Research Report
  • [Presentation] Ciliary disassembly by the enhanced PLK1-KIF2A pathway in a spindle assembly Checkpoint-deficiency syndrome2013

    • Author(s)
      Miyamoto T, Hosoba K, Ochiai H, Sakuma T, Yamamoto T, Matsuura S
    • Organizer
      The 25th CDB meeting
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of an extragenic mutation for PCS(MVA) syndrome and functional analysis using artificial-nucleases2013

    • Author(s)
      松浦伸也、落合博、宮本達雄、金井昭教、細羽康介、佐久間哲史、野地澄晴、山本卓
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of an extragenic mutation for PCS(MVA) syndrome and functional analysis using artificial-nucleases2013

    • Author(s)
      Miyamoto T, Ochiai H, Kanai A, Hosoba K, Kume S, Sakuma T, Yamamoto T, Matsuura S
    • Organizer
      ASHG 63rd annual meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト分裂期チェックポイント欠損症における繊毛形成異常2013

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      2013年 生体運動研究合同班会議
    • Place of Presentation
      東広島市
    • Related Report
      2012 Research-status Report
  • [Presentation] KIF2A phosphorylation by PLK1 regulates primary cilia disassembly2013

    • Author(s)
      Kosuke Hosoba, Tatsuo Miyamoto, Hiroshi Ochiai, Shinya Matsuura
    • Organizer
      The 2nd International Symposium of Phoenix Leader Education Program
    • Place of Presentation
      広島市
    • Related Report
      2012 Research-status Report
  • [Presentation] Artificial nuclease-based targeted DSB introduction and its application2013

    • Author(s)
      Hiroshi Ochiai, Tatsuo Miyamoto, Akinori Kanai, Kosuke Hosoba, Tetsushi Sakuma, Takashi Yamamoto, Shinya Matsuura
    • Organizer
      3rd International Symposium of RIRBM, Hiroshima University
    • Place of Presentation
      広島市
    • Related Report
      2012 Research-status Report
  • [Presentation] 人工ヌクレアーゼを利用した一塩基置換の導入2012

    • Author(s)
      落合博、宮本達雄、細羽康介、佐久間哲史、山本卓、松浦伸也
    • Organizer
      第2回ゲノム編集会
    • Place of Presentation
      岡崎
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 人工ヌクレアーゼを利用したゲノム編集研究の現状2012

    • Author(s)
      佐久間哲史、落合博、細井紗弥佳、宮本達雄、坂本尚昭、松浦伸也、山本卓
    • Organizer
      第2回ゲノム編集会
    • Place of Presentation
      岡崎
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ゲノム安定性を司る紡錘体チェックポイント因子BUBR1の間期中心体における機能2012

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      第53回原子爆弾後障害研究会
    • Place of Presentation
      長崎
    • Year and Date
      2012-06-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 紡錘体形成チェックポイント欠損症における分裂期キナーゼPLK1による一次繊毛抑制機構2012

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 人工ヌクレアーゼを利用した遺伝子間領域に存在する一塩基変異導入によるヒト疾患モデル細胞の樹立2012

    • Author(s)
      落合博、宮本達雄、金井昭教、細羽康介、佐久間哲史、野地澄晴、山本卓、松浦伸也
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 人工ヌクレアーゼTALENを利用した DSB導入とその応用2012

    • Author(s)
      落合博、宮本達雄、細羽康介、佐久間哲史、野地澄晴、山本卓、松浦伸也
    • Organizer
      日本放射線影響学会 第55回大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 分裂期キネシンを標的とした単極性紡錘体形成の誘導法の探索2012

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      日本放射線影響学会 第55回大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト遺伝性疾患の病因変異と考えられる遺伝子間領域に存在する一塩基多型(SNP)のZFNを利用した機能解析2012

    • Author(s)
      落合博、宮本達雄、細羽康介、山本卓、松浦伸也
    • Organizer
      第1回ゲノム編集会
    • Place of Presentation
      東広島
    • Related Report
      2013 Final Research Report
  • [Presentation] TALENの効率的作成法および評価法の確立と改良型ヌクレアーゼの開発2012

    • Author(s)
      佐久間哲史、細井紗弥佳、落合博、宮本達雄、松浦伸也、坂本尚昭、野地澄晴、山本卓
    • Organizer
      第1回ゲノム編集会
    • Place of Presentation
      東広島
    • Related Report
      2013 Final Research Report
  • [Presentation] Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes a ciliopathy with chromosomal instability2012

    • Author(s)
      Miyamoto T, Kikuchi A, Furutani-Seiki M, Matsuura S
    • Organizer
      International Symposium 50th anniversary of RIRBM, Hiroshima University
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] Targeted genome editing using transcription activator-like effector nucleases (TALENs)2012

    • Author(s)
      Sakuma T, Hosoi S, Ochiai H, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T
    • Organizer
      International Symposium 50th anniversary of RIRBM, Hiroshima University
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] 分裂期キネシンを標的とした単極性紡錘体形成の誘導法の探索2012

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      日本放射線影響学会 第55回大会
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] 紡錘体形成チェックポイント欠損症における分裂期キナーゼPLK1による一次繊毛抑制機構2012

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] 人工ヌクレアーゼを利用した遺伝子間領域に存在する一塩基変異導入によるヒト疾患モデル細胞の樹立2012

    • Author(s)
      落合博、宮本達雄、金井昭教、細羽康介、 佐久間哲史、野地澄晴、山本卓、 松浦伸也
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] 人工ヌクレアーゼTALENを利用したDSB導入とその応用2012

    • Author(s)
      落合博 、宮本達雄、 細羽康介、 佐久間哲史、野地澄晴、山本卓、 松浦伸也
    • Organizer
      日本放射線影響学会 第55回大会
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト遺伝性疾患の病因変異と考えられる遺伝子間領域に存在する一塩基多型(SNP)のZFNを利用した機能解析2012

    • Author(s)
      落合 博、宮本 達雄、細羽 康介、山本 卓、松浦 伸也
    • Organizer
      第1回ゲノム編集研究会
    • Place of Presentation
      広島
    • Related Report
      2011 Research-status Report
  • [Presentation] TALENの効率的作成法および評価法の確立と改良型ヌクレアーゼの開発2012

    • Author(s)
      佐久間 哲史、細井 紗弥佳、落合 博、宮本 達雄、松浦 伸也、坂本 尚昭、野地 澄晴、山本 卓
    • Organizer
      第1回ゲノム編集研究会
    • Place of Presentation
      広島
    • Related Report
      2011 Research-status Report
  • [Presentation] Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes a ciliopathy with chromosomal instability.2012

    • Author(s)
      Miyamoto T, Kikuchi A, Furutani-Seiki M, Matsuura S
    • Organizer
      International Symposium 50th anniversary of RIRBM, Hiroshima University
    • Place of Presentation
      広島
    • Related Report
      2011 Research-status Report
  • [Presentation] Targeted genome editing using transcription activator-like effector nucleases (TALENs).2012

    • Author(s)
      Sakuma T, Hosoi S, Ochiai H, Miyamoto T, Matsuura S, Sakamoto N, Yamamoto T
    • Organizer
      International Symposium 50th anniversary of RIRBM, Hiroshima University
    • Place of Presentation
      広島
    • Related Report
      2011 Research-status Report
  • [Presentation] 分裂期チェックポイント分子BUBR1欠損による高発がん性と繊毛病2011

    • Author(s)
      宮本達雄、松浦伸也
    • Organizer
      第52回原子爆弾後障害研究会
    • Place of Presentation
      広島
    • Year and Date
      2011-06-05
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] BUBR1, a mitotic spindle checkpoint regulator, plays a role of ciliogenesis in G0 phase2011

    • Author(s)
      Miyamoto T, Porazinski S, Wang H, Shimizu A, Kajii T, Kikuchi A, Furutani-Seiki M, Matsuura S
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Zinc-finger nuclease-mediated targeted transgene integration enables quantitative imaging of endogenous gene expression in living sea urchin embryos2011

    • Author(s)
      Ochiai H, Fujita K, Nishikawa M, Suzuki K, Matsuura S, Miyamoto T, Sakuma T, Sakamoto N, Shibata T, Yamamoto T
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 分裂期チェックポイント分子BUBR1は脊椎動物における繊毛形成を制御する2011

    • Author(s)
      宮本達雄、Porazinski S、 Wang H、清水厚志、梶井正、菊池章、古谷-清木誠、松浦伸也
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 繊毛病としての染色分体早期解離(PCS)症候群2011

    • Author(s)
      宮本達雄、古谷-清木誠、松浦伸也
    • Organizer
      第56回日本人類遺伝学会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] 紡錘体チェックポイント分子BUBR1はG0期において繊毛形成を制御する2011

    • Author(s)
      宮本達雄、菊池章、古谷-清木誠、松浦伸也
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] TALEヌクレアーゼ作製法の確立2011

    • Author(s)
      落合博、佐久間哲史、宮本達雄、野地澄晴、松浦伸也、山本卓
    • Organizer
      自然科学研究機構・基礎生物学研究所共同利用共同研究・研究会「遺伝子機能解析の最先端」
    • Place of Presentation
      岡崎
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Zinc-finger nuclease-mediated targeted transgene integration enables quantitative imaging of endogenous gene expression in living sea urchin embryo.2011

    • Author(s)
      Ochiai H, Jujita K, Nishikawa M, Suzuki K, Matsuura S, Miyamoto T, Sakuma T, Sakamoto N, Shibata T, Yamamoto T
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] BUBR1, a mitotic spindle checkpoint regulator, plays a role of ciliogenesis in G0 phase.2011

    • Author(s)
      Miyamoto T, Porazinski S, Wang H, Shimizu A, Kajii T, Kikuchi A, Furutani-Seiki M, Matsuura S.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 繊毛病としての染色分体早期解離(PCS)症候群2011

    • Author(s)
      宮本 達雄、古谷-清木 誠、松浦 伸也
    • Organizer
      第56回日本人類遺伝学会
    • Place of Presentation
      千葉
    • Related Report
      2011 Research-status Report
  • [Presentation] 分裂期チェックポイント分子BUBR1は脊椎動物における繊毛形成を制御する2011

    • Author(s)
      宮本 達雄、Sean Porazinski、 Huija Wang、清水 厚志、梶井 正、菊池 章、古谷-清木 誠、松浦 伸也
    • Organizer
      第54回日本放射線影響学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト培養細胞における一塩基編集技術:放射線感受性SNPの定量的評価系確立への試み

    • Author(s)
      宮本達雄、落合博、久米悟士、佐久間哲史、山本卓、松浦伸也
    • Organizer
      第38回中国地区放射線影響研究会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞増殖に連動した分裂期キネシン分子KIF2Aによる繊毛退縮機構

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      第54回原子爆弾後障害研究会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 人工ヌクレアーゼを用いたヒト培養細胞での一塩基編集:放射線感受性SNPの評価系構築への試み

    • Author(s)
      宮本達雄、落合博、金井昭教、久米悟士、佐久間哲史、山本卓、松浦伸也
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゲノム安定性を司る紡錘体チェックポイント因子BUBR1の間期中心体における機能

    • Author(s)
      宮本達雄、細羽康介、落合博、松浦伸也
    • Organizer
      第53回原子爆弾後障害研究会
    • Place of Presentation
      長崎市
    • Related Report
      2012 Research-status Report
  • [Presentation] 人工ヌクレアーゼを利用した一塩基置換の導入

    • Author(s)
      落合博 、宮本達雄、 細羽康介、 佐久間哲史、山本卓、 松浦伸也
    • Organizer
      第2回ゲノム編集研究会
    • Place of Presentation
      岡崎市
    • Related Report
      2012 Research-status Report
  • [Presentation] 人工ヌクレアーゼを利用したゲノム編集研究の現状

    • Author(s)
      佐久間哲史、 落合博、 細井紗弥佳、宮本達雄、 坂本尚昭、 松浦伸也、 山本卓
    • Organizer
      第2回ゲノム編集研究会
    • Place of Presentation
      岡崎市
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.natureasia.com/ja-jp/jobs/tokushu/detail/234

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.hiroshima-u.ac.jp/top/koho_press/press/h2301-12/p_m18fuk.html

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.hiroshima-u.ac.jp/top/koho_press/press/h2501-12/p_t2c07r.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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