Comprehensive study of the importance of miRNA on radiation-induced mammary carcinogenesis
| Project/Area Number |
23710071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
IIZUKA Daisuke 広島大学, 原爆放射線医科学研究所, 助教 (00455388)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 放射線誘発乳がん / マイクロRNA / がん幹細胞 / 放射線被ばく / mammosphere / 循環miRNA / miRNA |
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| Research Abstract |
In this study, I comprehensively analyzed the importance of microRNA (miRNA) on radiation-induced mammary carcinogenesis. The inhibition of miR-194 suppressed the cell growth rate in some human breast cancer cell lines. I obtained breast cancer stem cells under specific culture condition (mammosphere culture). In these cells, the upregulation of miR-22 was observed. The manipulation of miR-22 level changed not only the frequency of mammosphere formation but also the sensitivity to radiation exposure evaluated by colony formation assay. The upregulation of miR-194 in sera of rat radiation-induced mammary carcinoma model was observed in part but not significant.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Influence of age on the relative biological effectiveness of carbon ion radiation for induction of rat mammary carcinoma.2013
Author(s)
Imaoka T, Nishimura M, Daino K, Kokubo T, Doi K, Iizuka D, Nishimura Y, Okutani T, Takabatake M, Kakinuma S, Shimada Y
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 85
Issue: 4
Pages: 1134-40
DOI
Related Report
Peer Reviewed
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