| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
It is unclear whether radiation-induced breast cancer shows specific phenotypic and genotypic features and originates from cells at a specific differentiation stage. We evaluated the associations between genetic and phenotypic features of spontaneous, radiation-induced and chemically-induced rat mammary cancers. We revealed that clustering analyses of immunohistochemical and microarray-based gene expression profile data classified the cancers into several subtypes. Radiation-induced cancers were overrepresented in a specific subtype, which developed earlier than others. As this subtype has been reported to originate from a specific progenitor cell in humans and mice, the present results suggest that radiation-induced rat mammary cancer initiates in cells at a specific differentiation stage.
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