The roles of DNA repair genes during the mammary gland development and radiation-induced mammary tumorigenesis
| Project/Area Number |
23710075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
DAINO Kazuhiro 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 研究員 (90543299)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 乳腺 / 発生・分化 / 放射線 / DNA損傷修復 |
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| Research Abstract |
In this study, we obtained results suggesting that the differences in DNA damage response in developing mammary glands, and the DNA repair gene BRIP1 has important roles in promoting normal acinar morphogenesis and loss of BRIP1 disrupts acinar formation possibly through the dysregulation of multiple cellular signaling pathways. Since the expression levels of BRIP1 gene are reduced in rat mammary tumors-induced by ionizing radiation, BRIP1 may play important roles in radiation-induced mammary tumorigenesis.
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Report
(4 results)
Research Products
(7 results)
