The roles of DNA repair genes during the mammary gland development and radiation-induced mammary tumorigenesis

• Project/Area Number: 23710075
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: DAINO Kazuhiro 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 研究員 (90543299)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 乳腺 / 発生・分化 / 放射線 / DNA損傷修復

Research Abstract

In this study, we obtained results suggesting that the differences in DNA damage response in developing mammary glands, and the DNA repair gene BRIP1 has important roles in promoting normal acinar morphogenesis and loss of BRIP1 disrupts acinar formation possibly through the dysregulation of multiple cellular signaling pathways. Since the expression levels of BRIP1 gene are reduced in rat mammary tumors-induced by ionizing radiation, BRIP1 may play important roles in radiation-induced mammary tumorigenesis.

Research Products

• [Journal Article] Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis. (2013)
  • Author(s): Daino K, Imaoka T, Morioka T, Tani S, Iizuka D, Nishimura M, Shimada Y.
  • Journal Title: PLoS One Volume: 8 Issue: 9 Pages: e74013-e74013
  • DOI: 10.1371/journal.pone.0074013
  • Peer Reviewed
• [Presentation] BRCA1と相互作用するヘリカーゼ BRIP1の機能喪失は乳腺の腺管形成異常を引き起こす (2012)
  • Author(s): 臺野和広、今岡達彦、森岡孝満、西村まゆみ、島田義也
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡市
• [Presentation] Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis (2012)
  • Author(s): Kazuhiro Daino、Tatsuhiko Imaoka、Takamitsu、Morioka、Mayumi Nishimura、Yoshiya Shimada
  • Organizer: The 22nd Biennial Congress of the European Association for Cancer Research
  • Place of Presentation: Spain (Barcelona)
• [Presentation] BRCA1と相互作用するヘリカーゼBRIP1の機能喪失は乳腺の腺管形成異常を引き起こす (2012)
  • Author(s): 臺野 和広、今岡 達彦、森岡 孝満、西村 まゆみ、島田 義也
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡市
• [Presentation] Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis (2012)
  • Author(s): Kazuhiro Daino、Tatsuhiko Imaoka、Takamitsu Morioka、Mayumi Nishimura、Yoshiya Shimada
  • Organizer: The 22nd Biennial Congress of the European Association for Cancer Research
  • Place of Presentation: Spain: Barcelona
• [Presentation] Involvement of BRCA1-interacting helicase BRIP1 during acinar morphogenesis of mammary epithelial cells in a three-dimensional basement membrane culture (2011)
  • Author(s): Kazuhiro DAINO, Tatsuhiko IMAOKA, Mayumi NISHIMURA, and Yoshiya SHIMADA
  • Organizer: 第34回日本分子生物学学会年会
  • Place of Presentation: 横浜市
• [Presentation] Involvement of BRCA1-interacting helicase BRIP1 during acinar morphogenesis of mammary epithelial cells in a three-dimensional basement membrane culture (2011)
  • Author(s): 臺野 和広
  • Organizer: 第34回日本分子生物学学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）