Swift exploration of the receptor binding characteristics of low molecular weight endocrine disruptors for orphan nuclear receptors
| Project/Area Number |
23710080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyushu University |
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Principal Investigator |
LIU Xiaohui 九州大学, 理学研究院, 学術研究員 (60596849)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 有害化学物質 / 蛋白質 / 脳・神経 / 生理活性 / ビスフェノールA / ビスフェノールＡ |
|---|
| Research Abstract |
With no radiolabeled standard compound for the receptor-binding assay, it is difficult to make a structure-activity study especially for "orphan nuclear receptor." The SPR method requires no standard compound in receptor assay, and thus in this study, we intended to establish a novel way to perform SPR prior to the ordinary binding assay. By using non-radiolabeled compounds, we carried out SPR to explore the ligands of particular nuclear receptor, and those that bind to the receptor were then utilized for radio-ligand receptor binding assay. In several occasions, we could find out eventually a very specific chemical that strongly binds to a certain important nuclear receptor.
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Report
(3 results)
Research Products
(77 results)
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[Journal Article] Bisphenol-binding pocket of constitutively active nuclear receptor car: docking modeling for close-packing2013
Author(s)
Matsuyama, Y., Liu, X., Nishimura, H.,Matsushima, A., Nose, T., andShimohigashi, Y
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Journal Title
Peptide Science 2012
Pages: 401-402
NAID
Related Report
Peer Reviewed
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[Journal Article] The impact of bisphenol A-feeding on the Drosophila neuropeptide PDF mRNA structure2013
Author(s)
Matsuo, A., Nakamura, M., Takeda, Y., Matsuyama, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y
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Journal Title
Peptide Science 2012
Pages: 75-76
NAID
Related Report
Peer Reviewed
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[Presentation] Exposure of the Fruit Fly Drosophila to Bisphenol A Affects Alternative Polyadenylation of Neuropeptide PDF mRNA Gene
Author(s)
Matsuo, A., Nakamua, M., Takeda, Y., Matsuyama, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.
Organizer
16th Korean Peptide Protein Symposium
Place of Presentation
Sungkyunkwan University（成均館大學校）（Suwon水原市）
Related Report
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