| Project/Area Number |
23710080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyushu University |
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Principal Investigator |
LIU Xiaohui 九州大学, 理学研究院, 学術研究員 (60596849)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 有害化学物質 / 蛋白質 / 脳・神経 / 生理活性 / ビスフェノールA / ビスフェノールＡ |
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| Research Abstract |
With no radiolabeled standard compound for the receptor-binding assay, it is difficult to make a structure-activity study especially for "orphan nuclear receptor." The SPR method requires no standard compound in receptor assay, and thus in this study, we intended to establish a novel way to perform SPR prior to the ordinary binding assay. By using non-radiolabeled compounds, we carried out SPR to explore the ligands of particular nuclear receptor, and those that bind to the receptor were then utilized for radio-ligand receptor binding assay. In several occasions, we could find out eventually a very specific chemical that strongly binds to a certain important nuclear receptor.
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