Functionalized Conducting Polymer Nanostructures for Enhanced Capturing and Monitoring of Circulating Tumor Cells
| Project/Area Number |
23710138
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
LUO Shyh Chyang 独立行政法人理化学研究所, Yu 独立主幹研究ユニット, 基幹研究所研究員 (70565051)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 循環腫瘍細胞を捕捉 / 導電性ポリマー / ナノ構造 / スマート・マテリアル / 導電性高分子 / 循環腫瘍細胞 / バイオセンサー / 電気化学インピーダンス |
|---|
| Research Abstract |
During these two years, we have accomplished several tasks, including synthesis of functionalized conducting polymers for bioconjugation, the fabrication of conducting polymer nanostructures and the protocol design of circulating tumor cells (CTC) capturing. For nanostructure fabrication, we demonstrated both template and template-free methods. We observed that the capture efficiency was enhanced by 4 - 5 times comparing to smooth films. We also developed a cell capture and release platform using polymer-grafted silicon nanostructures as the platform.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article]2013
Author(s)
Lin, H.-A.; Luo, S.-C.; Zhu, B.; Yamashita, Y.; Yu, Hsiao-hua
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Journal Title
Adv. Funct. Mater.
Volume: 25(referred)
Issue: 25
Pages: 3212-3219
DOI
Related Report
Peer Reviewed
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[Journal Article] Capture and Stimulated Release of Circulating Tumor Cells on Polymer Grafted Silicon Nanostructures2013
Author(s)
Hou, S.; Zhao, H.; Zhao, L.; Shen, Q.; Wei, K. S.; Suh, D. Y.; Nakao, A.; Garcia, M. A.; Song, M.; Lee, T; Xiong, B.; Luo, Shyh-Chyang; Tseng, H. -R.; Yu, H. -h
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Journal Title
Advanced Materials
Volume: 25
Pages: 1547-1551
Related Report
Peer Reviewed
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[Presentation] Tunable, Dynamic and Electrically Stimulated Lectin-Carbohydrate Recognition on a Glycan-Grafted Conjugated Polymer2012
Author(s)
Luo, Shyh-Chyang, Zhu, B., Siang, Y. W., Kantchev, E. A. B., Yu, H. -h
Organizer
International Conference on Bioinspired and Biobased Chemistry & Materials
Place of Presentation
Nice, France
Related Report
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[Presentation] Nanostructured PEDOT Thin Films by Electropolymerization- Understanding Structure and Temperature Effect2011
Author(s)
Luo, Shyh-Chyang, Zhu, B., Sekine, J., Zhao, H. C., Yu, H. -h
Organizer
60th Society of Polymer Science, Japan
Place of Presentation
Osaka, Japan
Related Report
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