Visualization of Mechanical Response of Molecular Machines working in vivo
Project/Area Number |
23710144
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Nanomaterials/Nanobioscience
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 分子モーター / 分子機械 / 高圧力顕微鏡 / 水和 / べん毛モーター / 1分子計測 / バイオイメージング / タンパク質 / 高圧力 / バクテリア / タンパク質分子機械 / 1分子計測 |
Research Abstract |
In this research project, we developed a new assay that enables to control the functional expression of molecular machines working in living cells. We constructed a new high-pressure microscope that allows us to modulate the intermolecular interactions between protein and water molecules. By using this system, we were successful to change the rotational direction of Escherichia coli flagellar motors.
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Report
(4 results)
Research Products
(50 results)