The chromosomal territory influencing the regulation of gene expression in neuronal cells.
Project/Area Number |
23710215
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Genome biology
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Research Institution | Kanazawa University |
Principal Investigator |
HORIKE Shinichi 金沢大学, 学際科学実験センター, 准教授 (40448311)
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 自閉症 / インプリンティング / PWS-IC / 染色体ペアリング / 核内配置 / 染色体テリトリー / エピジェネティクス / ゲノムインプリンティング / クロマチンループ / コピー数多型 / トランスクロモソミックマウス / ヒト15番染色体 / DNAメチル化 / TCマウス |
Research Abstract |
I examined the chromosome territory of a human chromosome 15 in neuronal cells by using the chromosome engineering techniques. Finally, I found that active gene region of 15q11-q13 was looping out from the chromosome 15 territory. From my results, 15q11-q13 locus was highly coordinately regulated by PWS-IC.
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Report
(3 results)
Research Products
(37 results)
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[Presentation] Evidence for a hTERT repressor gene on human chromosome 3p21.3 by using chromosome engineering2011
Author(s)
Ohhira T., Abe S., Tanaka H., Notsu T., Horike S., Qi D.L., Fujisaki C., David G., Oshimura M., Kugoh H
Organizer
12th International Congress of Human Genetics and The ASHG 61stAnnual Meeting
Place of Presentation
Montreal, (CANADA)
Year and Date
2011-10-14
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