Research Project
Grant-in-Aid for Young Scientists (B)
Several neuron-specific genes placed in the AT-rich genomic environment are regulated by DNA topoisomerase (topo) IIβ. We have identified hnRNP U/SAF-A/SP120 as a protein associated with topo IIβ in differentiating cerebellar neurons. SP120 is a multifunctional nuclear protein that directly binds to DNA and RNA. SP120 specifically and cooperatively binds AT-rich matrix attachment regions (MAR). It was the reported that the N-terminal domain termed SAF-box was required for DNA binding and the C-terminal domain called RGG-box was essential for the interaction with RNA. We showed that a C-terminal domain enriched with Arg-Gly (RG domain) encompassing the RGG-box was important for the MAR-specific binding activity.
All 2012 2011 Other
All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (22 results) (of which Invited: 1 results) Remarks (3 results)
he international journal of developmental biology
Volume: 55巻 Pages: 933-943
International journal of developmental biology
Volume: 55 Issue: 10-11-12 Pages: 933-943
10.1387/ijdb.113326ao
http://nbgp.med.okayama-u.ac.jp/
