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Identification of allele-specific methylation regions involved in congenital genomic imprinting disorders

Research Project

Project/Area Number 23710223
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical genome science
Research InstitutionTohoku University

Principal Investigator

HIURA Hitoshi  東北大学, 医学(系)研究科(研究院), 助教 (70451523)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生殖補助医療 / インプリント / 生殖補助医療(ART) / 男性精子 / DNAメチル化 / ゲノムインプリント
Research Abstract

Recently, assisted reproductive technologies (ART) have become available to infertile couples who wish to have children. However, reports of rare imprinting disorders have been increased around the globe with the popularization of assisted reproductive technologies. In this study, to clarify the influence of ART for genomic imprinting and identify the ART-related risk factor(s), we analyzed the DNA methylation status of 22 differentially methylated regions in BWS and SRS patients. We observed a more widespread disruption of genomic imprints after ART. Our data suggest that ART-related risk factor(s) was a process after the fertilization than the gamete formative period.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Book (5 results)

  • [Journal Article] Stability of the abnormal imprinting of human induced pluripotent stem cells2013

    • Author(s)
      Hiura H, Toyoda M, Okae H, Sakurai M, Miyauchi N, Sato A, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Nishino K, Umezawa A, Arima T
    • Journal Title

      BMC Genetics

      Volume: 14 Issue: 1 Pages: 32-32

    • DOI

      10.1186/1471-2156-14-32

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation errors in imprinting disorders and assisted reproductive technologies.2013

    • Author(s)
      Chiba H, Hiura H, Okae H, Miyauchi N, Sato F, Sato A, Arima T.
    • Journal Title

      Pediatrics international.

      Volume: 55 Issue: 5 Pages: 542-549

    • DOI

      10.1111/ped.12185

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant DNA methylation of imprinted loci in male and female germ cells of infertile couples2012

    • Author(s)
      Arima T,Okae H, Hiura H, Miyauchi N, Sato F, Sato A, Hayashi C
    • Journal Title

      DNA METHYLATION INTECH

      Volume: 29 Pages: 183-192

    • URL

      http://www.intechopen.com/books/dna-methylation-from-genomics-to-technology

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput detection of aberrant imprint methylation in the ovarian cancer by the bisulphite PCR-Luminex method.2012

    • Author(s)
      Hiura H, Okae H, Kobayashi H, Miyauchi N, Sato F, Sato A, Suzuki F, Nagase S, Sugawara J, Nakai K, Yaegashi N, Arima T.
    • Journal Title

      BMC Medical Genomics

      Volume: 5 Issue: 1 Pages: 8-17

    • DOI

      10.1186/1755-8794-5-8

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproductive technologies.2012

    • Author(s)
      Hiura H, Okae H, Miyauchi N, Sato F, Sato A , Van De Pette M, John R M, Kagami M, Nakai K, Soejima H, Ogata T, Arima T.
    • Journal Title

      Human Reproduction

      Volume: 27(8) Issue: 8 Pages: 2541-2548

    • DOI

      10.1093/humrep/des197

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression2012

    • Author(s)
      Hiroaki Okae, et al
    • Journal Title

      Human Molecular Genetics

      Volume: 21 Issue: 3 Pages: 548-558

    • DOI

      10.1093/hmg/ddr488

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 生殖補助医療由来の先天性ゲノムインプリンティング異常症2012

    • Author(s)
      有馬隆博、樋浦仁、岡江寛明
    • Journal Title

      日本生殖内分泌学会雑誌 Japanese Journal of Reproductive Endocrinology

      Volume: 17 Pages: 54-58

    • NAID

      40019434316

    • Related Report
      2012 Research-status Report
  • [Journal Article] Aberrant DNA Methylation of Imprinted2012

    • Author(s)
      Arima T, Okae H, Hiura H et al
    • Journal Title

      INTECH

      Volume: 29 Pages: 183-192

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus2011

    • Author(s)
      Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D., Sasaki, H
    • Journal Title

      Science

      Volume: 332 Issue: 6031 Pages: 848-52

    • DOI

      10.1126/science.1203919

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessing loss of imprint methylation in sperm from subfertile men using novel methylation PCR-Luminex analysis2011

    • Author(s)
      Sato A, Hiura H, Okae H, Miyauchi N, Abe Y, Utsunomiya T, Yaegashi N, Arima T
    • Journal Title

      Fertil and Steril

      Volume: 95 Issue: 1 Pages: 129-134

    • DOI

      10.1016/j.fertnstert.2010.06.076

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Book] DNA METHYLATION2012

    • Author(s)
      Arima T, Okae H, Hiura H, Miyauchi N, Sato F, Sato A, Hayashi C.
    • Publisher
      INTECH
    • Related Report
      2012 Research-status Report
  • [Book] 産婦人科の実際2011

    • Author(s)
      有馬隆博、樋浦仁、岡江寛明、佐藤晶子、宮内尚子、阿部千鶴、林千賀
    • Publisher
      金原出版株式会社
    • Related Report
      2011 Research-status Report
  • [Book] 助産雑誌2011

    • Author(s)
      有馬隆博、樋浦仁、岡江寛明、佐藤晶子、宮内尚子
    • Publisher
      医学書院
    • Related Report
      2011 Research-status Report
  • [Book] 癌と化学療法2011

    • Author(s)
      有馬隆博、樋浦仁、岡江寛明、宮内尚子、佐藤芙美
    • Publisher
      癌と化学療法社
    • Related Report
      2011 Research-status Report
  • [Book] 卵子学2011

    • Author(s)
      有馬隆博、樋浦仁、岡江寛明、佐藤晶子、宮内尚子
    • Publisher
      京都大学学術出版会
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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