Transcription regulation by Transcription factors and Epigenetic factors
| Project/Area Number |
23710224
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical genome science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 疾患エピゲノミクス / 転写 / ゲノム / 心臓 / エピジェネティクス |
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| Research Abstract |
Human genome has over 20,000 genes. Transcription factors and epigenetic factors including histone modifiers, are pivotal factors for gene expression.Mutation in these genes causes congenital heart diseases. But it was still unclear which genes are regulated by these transcription factors. Here, we identified these transcription factors-binding genomic regions using next-generation sequencer, and the target genes that are regulated by these factors.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia.2011
Author(s)
Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath JA, Uitto J, Kaneda Y.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 108(16)
Issue: 16
Pages: 6609-14
DOI
Related Report
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[Journal Article] PDGFRα-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia.2011
Author(s)
Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath J A, Uitto J, Kaneda Y
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Related Report
Peer Reviewed
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