Functional analysis of ulcerative colitis susceptibility genes and implementation for clinical practice

• Project/Area Number: 23710225
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical genome science
• Research Institution: Kyushu University
• Principal Investigator: ASANO Kouichi 九州大学, 大学病院, 助教 (40593893)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 疾患関連遺伝子 / 潰瘍性大腸炎 / 遺伝子発現解析 / 予後予測 / 疾患関連遺伝子多型 / 遺伝子発現 / 臨床経過予測 / 遺伝子多型 / 臨床経過

Research Abstract

We have previousely identified ulcerative colitis (UC), an intractable disease, susceptibility genes, and we aimed to investigate further precise pathogenesis of the disease and to analyse effects of UC susceptibility genes on the clinical course. Analyses of UC susceptibility genes revealed that a copy numver variation region exist at FCGR3A gene and that allele copy number of FCGR3A located in this CNV region is associated with UC susceptibility. Next, we investigated effect of UC susceptibility genes on the relapse status of the disease. As a result, SNPs at FCGR2A gene and 13q region were associated with the risk of relapse of the disease. Thus, UC susceptibility genes revealed to not only play a role in the pathogenesis of the disease, but also have effects of the clinical course.

Research Products

• [Journal Article] Impact of Allele Copy Number of Polymorphisms in FCGR3A and FCGR3B Genes on Susceptibility to Ulcerative Colitis (2013)
  • Author(s): Kouichi Asano, Takayuki Matsumoto, Junji Umeno, Atsushi Hirano, Motohiro Esaki, Naoya Hosono, Toshiyuki Matsui, Yutaka Kiyohara, Yusuke Nakamura, Michiaki Kubo, and Takanari Kitazono
  • Journal Title: Inflammatory Bowel Diseases Volume: Sep;19(10) Pages: 2061-2068
• [Journal Article] Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis. (2013)
  • Author(s): Asano K, Matsumoto T, Umeno J, Hirano A, Esaki M, Hosono N, Matsui T, Kiyohara Y, Nakamura Y, Kubo M, Kitazono T.
  • Journal Title: Inflamm Bowel Dis Volume: 19 Issue: 10 Pages: 2061-2068
  • DOI: 10.1097/mib.0b013e318298118e
  • Peer Reviewed
• [Presentation] Ulcerative colitis susceptibility variants at FCGR2A and 13q12 predict disease couse (2014)
  • Author(s): Asano K, Esaki M, Umeno J, Maehata Y, Moriyama T, Nakamura S, Kitazono T
  • Organizer: Digestive Disease Week 2014
  • Place of Presentation: Chicago, USA
• [Presentation] Ulcerative colitis susceptibility variants at FCGR2A and 13q12 predict disease couse. (2014)
  • Author(s): Kouichi Asano
  • Organizer: Digestive disease Week 2014
  • Place of Presentation: Chicago, USA
• [Presentation] Impact of Allele Copy Number of Polymorphisms in the FCGR3A and FCGR3B Genes on susceptibility to Ulcerative Colitis (2011)
  • Author(s): Kouichi Asano, Junji Umeno, Tomohiko Moriyama, Motohiro Esaki, Shotaro Nakamura, Toshiyuki Matsui, and Takayuki Matsumoto
  • Organizer: Crohn’s & Colitis Foundation’s Clinical & Research Conference 2011
  • Place of Presentation: Hollywood, Florida, USA
• [Book] 胃と腸2013年増刊号 炎症性腸疾患の遺伝的背景 (2013)
  • Author(s): 浅野光一，梅野淳嗣，松本主之
  • Publisher: 医学書院