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Fine-mapping of disease susceptibility genes by ethnic comparison

Research Project

Project/Area Number 23710228
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical genome science
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

TAKEUCHI Fumihiko  国立感染症研究所, 病原体ゲノム解析研究センター, 室長 (50384152)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsゲノムワイド関連解析 / 国際情報交換 / 英国 / シンガポール / 精密マッピング / 人種差 / 連鎖不平衡 / 国際情報交流
Research Abstract

Genome-wide association studies have successfully identified genetic polymorphisms associated with diseases in numerous chromosomal regions. In this project, we aimed to develop a method to filter the causal variant in the chromosomal region by exploiting ethnic difference.
In the proposed method, we first separated the polymorphisms in a chromosomal region into groups having strong mutual linkage disequilibrium across multiple ethnic groups. Next, we selected representative polymorphisms from each groups, and filtered the group responsible for the disease using multiple regression.
We could narrow down possible causal variants in five regions associated with type 2 diabetes, in 12q24 associated ischemic heart disease and hypertension, and in 13q14 associated with Leprosy and Crohn’s disease. By combining association studies in multiple ethnic groups, we could filter the list of causal variants. By applying to various disease studies, the proposed method would enable earlier functional analysis and drug development.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies2013

    • Author(s)
      Wang X, Chua HX, Chen P, Ong RT, Sim X, Zhang W, Takeuchi F, Liu X, Khor CC, Tay WT, Cheng CY, Suo C, Liu J, Aung T, Chia KS, Kooner JS, Chambers JC, Wong TY, Tai ES, Kato N, Teo YY
    • Journal Title

      Hum. Mol. Genet

      Volume: 22 Issue: 11 Pages: 2303

    • DOI

      10.1093/hmg/ddt064

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of coronary artery disease in the Japanese2012

    • Author(s)
      Fumihiko Takeuchi, Mitsuhiro Yokota, et al.(他23名、3番目)
    • Journal Title

      Eur J Hum Genet

      Volume: 20 Issue: 3 Pages: 333

    • DOI

      10.1038/ejhg.2011.184

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians2011

    • Author(s)
      Yamori Y
    • Journal Title

      Nat Genetics

      Volume: 43 Issue: 6 Pages: 531

    • DOI

      10.1038/ng.834

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] T2D-GENES consortium Fine-Mapping of Type 2 Diabetes Susceptibility Loci via Trans-Ethnic Meta-Analysis2012

    • Author(s)
      Horikoshi M, Wiltshire S, Ferreira T, Kato N,Huyghe J, Mahajan A, Takeuchi F, Teo YY, Zeggini E, Morris A, McCarthy M
    • Organizer
      72nd Scientific Sessions of the American Diabetes Associations
    • Place of Presentation
      フィラデルフィア(米国)
    • Year and Date
      2012-06-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Fine-Mapping of Type 2 Diabetes Susceptibility Loci via Trans-Ethnic Meta-Analysis2012

    • Author(s)
      Momoko Horikoshi
    • Organizer
      72nd Scientific Sessions of the American Diabetes Associations
    • Place of Presentation
      フィラデルフィア(米国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Trans-ethnic fine-mapping of Type 2 Diabetes susceptibility loci using a "Cosmopolitan" reference panel for imputation2011

    • Author(s)
      Horikoshi M, Wiltshire S, Kato N, Asimit J, Rayner N, Robertson N, Takeuchi F, Mahajan A, Teo YY, Zeggini E, Morris A, McCarthy M
    • Organizer
      61th annual meeting of the American Society of Human Genetics
    • Place of Presentation
      モントリオール(カナダ)
    • Year and Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Fine-mapping of 13q14 locus associated with susceptibility to leprosy and Crohn's disease2011

    • Author(s)
      Takeuchi F
    • Organizer
      61th annual meeting of the American Society of Human Genetics
    • Place of Presentation
      モントリオール(カナダ)
    • Year and Date
      2011-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Fine-mapping of 13q14 locus associated with susceptibility to leprosy and Crohn’s disease2011

    • Author(s)
      Takeuchi, F
    • Organizer
      61th annual meeting of the American Society of Human Genetics
    • Place of Presentation
      モントリオール(カナダ)
    • Related Report
      2011 Research-status Report
  • [Presentation] Trans-ethnic fine-mapping of Type 2 Diabetes susceptibility loci using a "Cosmopolitan" reference panel for imputation2011

    • Author(s)
      M. Horikoshi, S. Wiltshire, N. Kato, J. Asimit, N. Rayner, N. Robertson, F. Takeuchi, A. Mahajan, T. Yik Ying, E. Zeggini, A. Morris, M. McCarthy
    • Organizer
      61th annual meeting of the American Society of Human Genetics
    • Place of Presentation
      モントリオール(カナダ)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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