| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
The signaling network in a germline cell was modeled using BmN4, the cell line derived from a Bombyx mori ovary. The network model is composed of genes that are evolutionarily conserved between B. mori and Drosophila melanogaster and that have been known as regulators for signal transduction in D. melanogaster germline or somatic cell development. The model suggested a gene known as a regulator of germline development in D. melanogaster as a hub in the network. In addition, the model inferred roles of genes of which mutations caused sterility by unknown reasons. Furthermore, the model inferred roles of genes, which have been known to function in somatic cells, in germline cells.
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