Production of novel fungal secondary metabolites by epigenetically activating the silent biosynthetic gene clusters.
| Project/Area Number |
23710248
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 天然物 / 二次代謝物 / 糸状菌 / 二次代謝制御 / エピジェネティクス / ヒストン脱 アセチル化酵素 / 酵素阻害剤 / 昆虫寄生菌 / 休眠遺伝子 / 物質生産 / 生物活性物質 / 二次代謝産物 / 天然物化学 / 生理活性物質 / ヒストン脱アセチル化酵素阻害剤 / DNAメチル化酵素阻害剤 |
|---|
| Research Abstract |
In this study, we found some effective conditions for activating fungal secondary metabolism by using epigenetic modifiers such as HADC and DNA methyltransferase inhibitors. Using the conditions, we successfully isolated structurally diverse novel fungal secondary metabolites from cryptic biosynthetic pathways, showing the utility to enlarge chemical space composed of natural products. In addition, we obtained the evidence that over expression of LaeA, an epigenetic enzyme, in fungi is possible way to enhance their production of secondary metabolites.
|
Report
(3 results)
Research Products
(33 results)
-
-
-
-
[Journal Article] An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii2013
Author(s)
Y. M. Chung, C. K. Wei, D. W. Chuang, M. E. Shazly, C. T. Hsieh, T. Asai, Y. Oshima, T. J. Hsieh, T. L. Hwang, Y. C. Wu, F. R. Chang
-
Journal Title
Bioorg. Med. Chem
Volume: 21
Issue: 13
Pages: 3866-3872
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
