| Project/Area Number |
23710257
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 活性発現の分子機構 / 生体分子 / 生理活性 / タンパク質 / 蛋白質 |
|---|
| Research Abstract |
In this study, I examined to elucidate the characterization ofosteopontin polymerized by protein crosslinking enzyme, transglutaminase 2. First, recognition site of an integrin alpha9beta1 in the polymeric osteopontin was determined. Next, using several inflammation-model mice, polymeric osteopontin appeared and increased according to inflammation, and was thought to be required for progression of inflammation.
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