Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Research Abstract |
Library synthesis of destruxin E utilizing solid-phase synthesis has been achieved. Parallel synthesis of the cyclization precursors was performed by solid-phase peptide synthesis. After cleavage from the polymer-support, MNBA-mediated macrolactonization in solution-phase, followed by the epoxide formation furnished destruxin E library containing side chain- or ring size-modified derivatives.
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