| Project/Area Number |
23710271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Osaka University |
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Principal Investigator |
HAZAMA Hisanao 大阪大学, 大学院・工学研究科, 助教 (70437375)
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| Research Collaborator |
MORIGUCHI Naoki 大阪大学, 大学院・工学研究科, 博士前期課程
HAMANAKA Tomonori 大阪大学, 工学部
KANNNEN Hiroki 大阪大学, 工学部
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分子イメージング / 薬物動態 / イメージング質量分析 / 投影型 / マトリックス支援レーザー脱離イオン化 |
|---|
| Research Abstract |
Technical developments were performed for high-throughput measurement of pharmacokinetics using stigmatic imaging mass spectrometry withmatrix-assisted laser desorption/ionization. Optimum ionization conditions for the drug were investigated, and a sample translation device operating under high vacuum was developed. The spatial distribution of the drug in a brain of a mouse was successfully observed by using the investigated ionization conditions and the improved mass spectrometer.
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