Development of high-throughput measurement techniques of pharmacokinetics using stigmatic imaging mass spectrometry
| Project/Area Number |
23710271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Osaka University |
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Principal Investigator |
HAZAMA Hisanao 大阪大学, 大学院・工学研究科, 助教 (70437375)
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| Research Collaborator |
MORIGUCHI Naoki 大阪大学, 大学院・工学研究科, 博士前期課程
HAMANAKA Tomonori 大阪大学, 工学部
KANNNEN Hiroki 大阪大学, 工学部
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分子イメージング / 薬物動態 / イメージング質量分析 / 投影型 / マトリックス支援レーザー脱離イオン化 |
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| Research Abstract |
Technical developments were performed for high-throughput measurement of pharmacokinetics using stigmatic imaging mass spectrometry withmatrix-assisted laser desorption/ionization. Optimum ionization conditions for the drug were investigated, and a sample translation device operating under high vacuum was developed. The spatial distribution of the drug in a brain of a mouse was successfully observed by using the investigated ionization conditions and the improved mass spectrometer.
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Report
(3 results)
Research Products
(39 results)
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[Presentation] Novel stigmatic mass microscope using laser ionization2012
Author(s)
Hisanao Hazama and Kunio Awazu
Organizer
International Joint Symposium on Single-Cell Analysis (The 6th International Workshop on Approaches to Single-Cell Analysis & The 8th International Forum on Post-Genome Technologies)
Place of Presentation
Kyoto Research Park, Kyoto, Japan
Year and Date
2012-11-27
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[Presentation] Observation of tissue sections using a stigmatic mass microscope with a multi-turn time-of-flight mass spectrometer2011
Author(s)
Hisanao Hazama, Hidetoshi Yoshimura, Jun Aoki, Hirofumi Nagao, Y asuhide Naito, Michisato Toyoda, Katsuyoshi Masuda, Kenichi Fujii, Toshio Tashima, and Kunio Awazu
Organizer
59th ASMS Conference on Mass Spectrometry and Allied Topics
Place of Presentation
Colorado Convention Center, Denver, CO, USA
Year and Date
2011-06-07
Related Report
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