| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The method for NMR difference spectroscopy using microcoils has been investigated. Other spectroscopy offers difference spectroscopy to acquire high signal-noise ratio spectra. However, NMR, suffered from its lowest sensitivity at any time, didn't use difference spectroscopy, because NMR spectra are strongly affected by the homogeneity of a magnetic field. Microcoil NMR is better method to acquire good NMR signals from the small amount of samples. It offers very high signal-noise ratio per sample mass and is very effective for an application using precious samples such as Fragment-Based Drug Discovery. These two methods are combined and the problem of field homogeneity mentioned above was solved in this project.
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