Effect of Ethereal Oxygens on the Biological Activities of Ladder-Shaped Polyethers
| Project/Area Number |
23710274
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Kyushu University |
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Principal Investigator |
TORIKAI Kohei 九州大学, 理学(系)研究科(研究院), 助教 (20456990)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | バイオプローブ / 梯子状ポリエーテル / 海産毒 / 活性発現機構 |
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| Research Abstract |
Ladder-shaped polyethers are mainly marine toxins produced by dinoflagellates. The objective of this research was to clarify how the ladder-shaped polyethers work in our bodies to exert their toxicity.
In the synthetic studies of natural products, basic parts (building blocks) are first synthesized and a target molecule will be built up using these parts. However, in this research, we faced difficulties in synthesizing a large quantity of parts by traditional methods. Therefore, novel recipe was established to supply enough building blocks successfully. This result will drastically accelerate the building-up works, being challenged all over the world.
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Report
(4 results)
Research Products
(19 results)
