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Effect of Ethereal Oxygens on the Biological Activities of Ladder-Shaped Polyethers

Research Project

Project/Area Number 23710274
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Chemical biology
Research InstitutionKyushu University

Principal Investigator

TORIKAI Kohei  九州大学, 理学(系)研究科(研究院), 助教 (20456990)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsバイオプローブ / 梯子状ポリエーテル / 海産毒 / 活性発現機構
Research Abstract

Ladder-shaped polyethers are mainly marine toxins produced by dinoflagellates. The objective of this research was to clarify how the ladder-shaped polyethers work in our bodies to exert their toxicity.
In the synthetic studies of natural products, basic parts (building blocks) are first synthesized and a target molecule will be built up using these parts. However, in this research, we faced difficulties in synthesizing a large quantity of parts by traditional methods. Therefore, novel recipe was established to supply enough building blocks successfully. This result will drastically accelerate the building-up works, being challenged all over the world.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (11 results) (of which Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Synthesis and Biological Activity of the C'D'E'F' Ring System of Maitotoxin2014

    • Author(s)
      Kunitake, M.; Oshima, T.; Konoki, K.; Ebine, M.; Torikai, K.; Murata, M.; Oishi, T.
    • Journal Title

      J. Org. Chem.

      Volume: (in press) Issue: 11 Pages: 4948-4962

    • DOI

      10.1021/jo5005235

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Facile and Practical Synthesis of Nicolaou's Key Intermediates, 2-Methyl-and 2,6-Dimethyl-Tetrahydropyrans, toward the Total Synthesis of Ladder-Shaped Polyethers2013

    • Author(s)
      Nakashima, T.; Baba, T.; Onoue, H.; Yamashita, W.; Torikai, K.
    • Journal Title

      Synthesis

      Volume: 45 Issue: 17 Pages: 2417-2425

    • DOI

      10.1055/s-0033-1338503

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca2+ influx in rat glioma C6 cells2012

    • Author(s)
      Oishi, T.; Konoki, K.; Tamate, R.; Torikai, K.; Hasegawa, F.; Matsumori, N.; Murata, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 22 Issue: 11 Pages: 3619-3622

    • DOI

      10.1016/j.bmcl.2012.04.053

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Practical Synthesis of DOPA Derivative for Biosynthetic Production of Potent Antitumor Natural Products, Saframycins and Ecteinascidin 7432011

    • Author(s)
      Kohei Torikai
    • Journal Title

      Letters in Organic Chemistry

      Volume: 8 Issue: 10 Pages: 686-689

    • DOI

      10.2174/157017811799304160

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 梯子状ポリエーテル類の合成に有用なテトラヒドロピラン誘導体の実用的合成2013

    • Author(s)
      鳥飼浩平・中嶋勇晴・馬場萌未・尾上久晃・山下航
    • Organizer
      統合物質創製化学推進事業第4回若手研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Design and Synthesis of Artificial Compounds; A Natural Product-Driven Research2013

    • Author(s)
      Kohei Torikai
    • Organizer
      Special Seminar in Pharmaceutical Sciences, Walailak University -Marine Natural Product Research in a Stream from Organic Chemistry to Chemical Biology-
    • Place of Presentation
      Nakhon Si Thammarat, Thailand
    • Year and Date
      2013-02-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 梯子状ポリエーテル類の合成に有用なテトラヒドロピラン誘導体の実用的合成2013

    • Author(s)
      鳥飼浩平・中嶋勇晴・馬場萌未・尾上久晃・山下 航
    • Organizer
      統合物質創製化学推進事業第4回若手研究会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食中毒シガテラの解毒剤開発を志向したマイトトキシンアンタゴニストの創製2013

    • Author(s)
      鳥飼浩平・國武政宏・中嶋勇晴・馬場萌未・尾上久晃・山下 航・海老根真琴・大石 徹
    • Organizer
      東京生化学研究会助成報告会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Design and Synthesis of Artificial Compounds; A Natural Product-Driven Research2013

    • Author(s)
      Torikai, K.
    • Organizer
      Walailak University Special Seminar in Pharmaceutical Sciences, "Marine Natural Product Research in a Stream from Organic Chemistry to Chemical Biology"
    • Place of Presentation
      Walailak Univ., Nakhon Si Thammarat, Thailand
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 梯子状ポリエーテル類の全合成に有用なテトラヒドロピラン誘導体の効率的合成2012

    • Author(s)
      鳥飼浩平・馬場萌未・中嶋勇晴・山下航・尾上久晃・大石徹
    • Organizer
      第3回統合物質シンポジウム「新エネルギーと物質創製」
    • Place of Presentation
      福岡
    • Year and Date
      2012-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 梯子状ポリエーテル類の全合成に有用なテトラヒドロピラン誘導体の効率的合成2012

    • Author(s)
      鳥飼浩平・馬場萌未・中嶋勇晴・山下 航・尾上久晃・大石 徹
    • Organizer
      第3回統合物質シンポジウム「新エネルギーと物質創製」
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Design and Synthesis of Artificial Ladder-Shaped~2012

    • Author(s)
      Torikai, K. et al.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Ventura, CA, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Design and Synthesis of Artificial Ladder-Shaped~2011

    • Author(s)
      Torikai, K. et al.
    • Organizer
      International ERATO Symposium
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Presentation] 天然物の働きを知るためにモノを設計・合成する有機化学2011

    • Author(s)
      鳥飼浩平
    • Organizer
      九州大学理学部化学科平成23年度前期特別談話会(招待講演)
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] 梯子状ポリエーテル類のケミカルバイオロジー研究を目指して2011

    • Author(s)
      鳥飼浩平
    • Organizer
      第46回天然物化学談話会(招待講演)
    • Place of Presentation
      静岡
    • Related Report
      2011 Research-status Report
  • [Book] Chembiomolecular Science: At the Frontier of Chemistry and Biology2012

    • Author(s)
      Oishi, T.; Konoki, K.; Tamate, R.; Torikai, K.; Hasegawa, F.; Nakashima, T.; Matsumori, N.; Murata, M.
    • Total Pages
      12
    • Publisher
      Springer Japan
    • Related Report
      2012 Research-status Report
  • [Remarks] アウトリーチ活動(高等学校及び企業向け講演会):Kohei Torikai, Seminar in OP Biofactory, "Role of Synthetic Organic Chemistry in the Research of Natural Products and Drug Discovery" 15th October, 2013, OP Biofactory, Co. Ltd., Uruma, Okinawa.

    • Related Report
      2013 Final Research Report
  • [Remarks] アウトリーチ活動(高等学校及び企業向け講演会):鳥飼浩平,大分東明高等学校講演会,第一部「理系進学からこれまで」,第二部「海洋天然毒を最新有機化学で攻略」,2012年6月20日,大分.

    • Related Report
      2013 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/faculty2_j.cgi?ID=K003874

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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