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Genome wide association analysis of age at menarche, menopause and menses cycle

Research Project

Project/Area Number 23710316
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gender
Research InstitutionThe University of Tokyo

Principal Investigator

TANIKAWA Chizu  東京大学, 医科学研究所, 助教 (30422421)

Co-Investigator(Renkei-kenkyūsha) MATSUDA Koichi  東京大学, 医科学研究所, 准教授 (90401257)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords科学技術 / 医療 / 生命 / ゲノムワイド関連解析
Research Abstract

Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identify the genetic factors associated with AAM, we conducted a large scale meta-analysis of genome-wide association studies using more than15,000 Japanese female samples. Here we identified an association between SNP (single nucleotide polymorphism) rs364663 at the LIN28B locus and AAM, with a P-value of 5.49 x10-7 and an effect size of 0.089 (year). We also evaluated 33 SNPs that were previouslyreported to be associated with AAM in women of European ancestry. Among them, two SNPs rs4452860 and rs7028916 in TMEM38B indicated significant association with AAM in the same directions as reported in previous studies (P = 0.0013 with an effect size of0.051) even after Bonferroni correction for the 33 SNPs. Our findings elucidated the impact of genetic variations on AAM in the Japanese population.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 10 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Identification of a functional variant in the MICA promoter whichregulates MICA expression and increases HCV-related hepatocellular carcinoma risk2013

    • Author(s)
      P.H. Yi Lo, Y. Urabe, V. Kumar, C. Tanikawa, K. Koike, N. Kato, D. Miki, K. Chayama, M. Kubo, Y. Nakamura, K. Matsuda
    • Journal Title

      PloS one

      Volume: 8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impact of four loci on serum tamsulosin hydrochloride concentration2013

    • Author(s)
      R. Takata, K. Matsuda, J. Sugimura, W. Obara, T. Fujioka, K. Okihara, N. Takaha, T. Miki, S. Ashida, K. Inoue, C. Tanikawa, T. Shuin, S. Sasaki, Y. Kojima, K. Kohri, M. Kubo, M. Yamaguchi, Y. Ohnishi, Y. Nakamura
    • Journal Title

      J Hum Genet

      Volume: 58 Pages: 21-26

    • NAID

      10031145896

    • Related Report
      2012 Final Research Report
  • [Journal Article] A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region2013

    • Author(s)
      Y. Urabe, H. Ochi, N. Kato, V. Kumar, A. Takahashi, R. Muroyama, N. Hosono, M. Otsuka, R. Tateishi, P.H. Lo, C. Tanikawa, M. Omata, K. Koike, D. Miki, H. Abe, N.Kamatani, J. Toyota, H. Kumada, M. Kubo, K. Chayama, Y. Nakamura, K. Matsuda
    • Journal Title

      Journal of hepatology

      Volume: 58 Pages: 875-82

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impact of four loci on serum tamsulosin hydrochloride concentration2013

    • Author(s)
      Takata Ryo, Matsuda Koichi, Sugimura Jun, Obara Wataru, Fujioka Tomoaki, Okihara Koji, Takaha Natsuki, Miki Tsuneharu, Ashida Shingo, Inoue Keiji, Tanikawa Chizu, Shuin Taro, Sasaki Shoichi, Kojima Yoshiyuki, Kohri Kenjiro, Kubo Michiaki, Yamaguchi Masao, Ohnishi Yozo, Nakamura Yusuke
    • Journal Title

      Journal of Human Genetics

      Volume: 58 Issue: 1 Pages: 21-26

    • DOI

      10.1038/jhg.2012.126

    • NAID

      10031145896

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a Functional Variant in the MICA Promoter Which Regulates MICA Expression and Increases HCV-Related Hepatocellular Carcinoma Risk.2013

    • Author(s)
      Lo PH, Urabe Y, Kumar V, Tanikawa C, Koike K, Kato N, Miki D, Chayama K, Kubo M, Nakamura Y, Matsuda K.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 4 Pages: e61279-e61279

    • DOI

      10.1371/journal.pone.0061279

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study of HCV-induced liver cirrhosis in the Japanese populationidentifies novel susceptibility loci at the MHC region2013

    • Author(s)
      Otsuka M
    • Journal Title

      J Hepatol

      Volume: I(n press) Issue: 5 Pages: 875-882

    • DOI

      10.1016/j.jhep.2012.12.024

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population2012

    • Author(s)
      C. Tanikawa, Y. Urabe, K. Matsuo, M. Kubo, A. Takahashi, H. Ito, K. Tajima, N. Kamatani, Y. Nakamura, K. Matsuda
    • Journal Title

      Nat Genet

      Volume: 44

    • Related Report
      2012 Final Research Report
  • [Journal Article] Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma.2012

    • Author(s)
      Kumar V, et. al.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 9 Pages: e44743-e44743

    • DOI

      10.1371/journal.pone.0044743

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.2012

    • Author(s)
      Tanikawa C, Urabe Y, Matsuo K, Kubo M, Takahashi A, Ito H, Tajima K, Kamatani N, Nakamura Y, Matsuda K.
    • Journal Title

      Nat Genet.

      Volume: 44 Issue: 4 Pages: 430-434

    • DOI

      10.1038/ng.1109

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulation of histone modification and chromatin structure by the p53-PADI4 pathway2012

    • Author(s)
      Tanikawa C, Espinosa M, Suzuki A, Masuda K, Yamamoto K, Tsuchiya E, Ueda K, Daigo Y, Nakamura Y, Matsuda K.
    • Journal Title

      Nat Commun.

      Volume: 3 Issue: 1 Pages: 676-676

    • DOI

      10.1038/ncomms1676

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CLCA2 as a p53-inducible senescence mediator2012

    • Author(s)
      C.Tanikawa, H.Nakagawa, Y.Furukawa, Y.Nakamura, K.Matsuda
    • Journal Title

      Neoplasia

      Volume: 14 Issue: 2 Pages: 141-149

    • DOI

      10.1593/neo.111700

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.2012

    • Author(s)
      Urabe Y, Tanikawa C, Takahashi A, Okada Y, Morizono T, Tsunoda T, Kamatani N, Kohri K, Chayama K, Kubo M, Nakamura Y, Matsuda K.
    • Journal Title

      PLoS Genet.

      Volume: 8 Issue: 3 Pages: 134-42

    • DOI

      10.1371/journal.pgen.1002541

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility2011

    • Author(s)
      V.Kumar, K.Matsuo, A.Takahashi, N.Hosono, T.Tsunoda, N.Kamatani, S.Y.Kong, H.Nakagawa, R.Cui, C.Tanikawa, M.Seto, Y.Morishima, M.Kubo, Y.Nakamura, K.Matsuda
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Issue: 6 Pages: 436-439

    • DOI

      10.1038/jhg.2011.35

    • NAID

      10030659704

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population2011

    • Author(s)
      R.Cui, Y.Okada, S.G.Jang, J.L.Ku, J.G.Park, Y.Kamatani, N.Hosono, T.Tsunoda, V.Kumar, C.Tanikawa, N.Kamatani, R.Yamada, M.Kubo, Y.Nakamura, K.Matsuda
    • Journal Title

      Gut

      Volume: 60 Issue: 6 Pages: 799-805

    • DOI

      10.1136/gut.2010.215947

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome wide association study of age at menarche in the Japanese population

    • Author(s)
      C. Tanikawa, Y. Okada, A. Takahashi, K. Oda, N. Kamatani, M. Kubo, Y. Nakamura, K. Matsuda
    • Journal Title

      PloS one

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Impact of PSCA variation on gastric ulcer susceptibility

    • Author(s)
      C. Tanikawa, K. Matsuo, M. Kubo, A. Takahashi, H. Ito, H. Tanaka, Y. Yatabe, K. Yamao, N. Kamatani, K. Tajima, Y. Nakamura, K. Matsuda
    • Journal Title

      PloS one

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Presentation] A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population2012

    • Author(s)
      Chizu Tanikawa, Yuji Urabe, Keitaro Matsuo, Hidemi Ito, Kazuo Tajima,Yusuke Nakamura,Koichi Matsuda
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] p53-PADI4経路によるヒストン修飾およびクロマチン構造の制御2011

    • Author(s)
      Chizu Tanikawa, Yataro Daigo, Yusuke Nakamura, Koichi Matsuda
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] Regulation of histone modification and chromatin structure by p53-PADI4 pathway

    • Author(s)
      Chizu Tanikawa, Koichi Matsuda, Yusuke Nakamura
    • Organizer
      103th AACR Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population

    • Author(s)
      Chizu Tanikawa, Yuji Urabe, Keitaro Matsuo, Hidemi Ito, Kazuo Tajima,Yusuke Nakamura, Koichi Matsuda
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of histone citrullination through p53/PADI4 network in carcinogenesis.

    • Author(s)
      Chizu Tanikawa, Koichi Matsuda, Yusuke Nakamura
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of histone citrullination through p53/PADI4 network in carcinogenesis.

    • Author(s)
      Chizu Tanikawa, Yusuke Nakamura, Koichi Matsuda
    • Organizer
      第9回 日米癌合同会議
    • Place of Presentation
      ハイアットリージェンシー、マウイ 米国
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/nakamura/matsuda/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/nakamura/matsuda/R%20s.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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