| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We investigated the physico-chemical properties of membrane domains that function signal transduction and molecular trafficking of cells. Under the control of the membrane tension by osmotic pressure, we observed a change in domain structures. We determined a quantitative phase diagram of phase organization with respect to the applied pressure and temperature. The results indicate that membrane tension can induce phase separation in homogeneous membranes. In addition, we investigated the interaction between domains and nanoparticles. We found that lateral heterogeneity in the membrane mediates the partitioning of nanoparticles in a size-dependent manner: small particles with a diameter of <200 nm were localized in an ordered phase, whereas large particles preferred a fluidic disordered phase.
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