Study on Mesoscopic Dynamics of Proteins in Aqueous Solution by Means of Neutron Scattering
| Project/Area Number |
23740323
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
ENDO Hitoshi 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究副主幹 (40447313)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | タンパク質構造 / タンパク質ダイナミクス / Staphylococcal Nuclease / 中性子散乱 / 中性子スピンエコー / 中性子小角散乱 / タンパク質 / ダイナミクス / タンパク質溶液 / Staphylococcal nuclease / 中性子スピンエコー法 |
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| Research Abstract |
Structure and dynamics of a protein in aqueous solution were investigated by small-angle neutron scattering (SANS) and neutron spin echo (NSE) technique. Staphylococcal nuclease (SNase) was used as a model protein, and the SANS experiments were performed with BL15 “Taikan” diffractometer at MLF, J-PARC; and the NSE measurements were done by using IN15 spectrometer at ILL in France. The obtained scattering data were quantitatively analyzed, which led to the evaluation of the structure and dynamics of SNase in aqua.
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Report
(3 results)
Research Products
(15 results)
