Molecualr dynamics study on the molecuar permeability of membrane protein
| Project/Area Number |
23750008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
SAITO Hiroaki 金沢大学, 数物科学系, 助教 (40506820)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 分子動力学法 / 脂質二重層膜 / 膜タンパク質 / 自由エネルギー / ペプチド / イオンチャネル / 溶媒和自由エネルギー / 分子動力学 / グラミシジン |
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| Research Abstract |
We have carried out molecular dynamics simulations to analysis the structure and dynamics of peptide and membrane protein in several lipid bilayer environments and have investigated the ion and molecular permeability through the channel of membrane protein. The thermal stability of membrane protein in the lipid bilayers has also been investigated by free energy calculation.
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Report
(4 results)
Research Products
(141 results)
