Design of chiral calix arene for synthesis of optically-active unnatural amino acids by asymmetric complexation
| Project/Area Number |
23750037
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Niigata University |
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Principal Investigator |
TAYAMA Eiji 新潟大学, 自然科学系, 准教授 (90372474)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 不斉包接 / 転位反応 / 四級アンモニウム塩 / アミノ酸 / 不斉合成 / 有機触媒 / 光学活性 / 包接 |
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| Research Abstract |
Optically-active large cyclic compounds were prepared from calix arenes. NMR analysis of a 1:1 complex between the chiral calix arene and a racemic tetraalkylamkmonium salt was examined. Each enantiomer of the tetraalkylammonium salt were observed separately in the spectrum. Asymmetric rearrangements of the tetraalkylammonium salts using the chiral calix arenes as an organo-catalyst were examined. The rearrangement products were successfully converted to the corresponding unnatural amino acids.
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Report
(4 results)
Research Products
(11 results)
