| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
A separation-oriented derivatization method for highly accurate and precise LC-MS/MS analysis of target analytes has been developed utilizing affinity of perfluoroalkyl group and one another, namely fluorous. In this method, the matrix-induced effects during LC-MS analysis could be eliminated because the perfluoroalkylated analytes could be retained specifically on a perfluoroalkyl-modified LC column, whereas non-fluorous endogenous matrix components were poorly retained under the separation conditions.
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