| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
Dynamic substrates that change surface cell adhesiveness in response to an extracellular stimulus are useful for fundamental biological studies as well as tissue engineering applications. This project focused on the development and applications of photo-responsive “caged culture substrates”. By functionalization of a surface with the controlled amino group density, we succeeded in improving the photoswitching efficiency. Furthermore, by analyzing cell migration in controlled cellular microenvironments, we found that the cells achieve collective characteristics as increasing cluster size as well as incubation time.
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