Development of highly efficient micro-flow synthetic method for activated vitamin D3s using a continuous-multi step microflow reactor
| Project/Area Number |
23750101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ビタミンD3 / 光反応 / 熱反応 / マイクロフロー反応 / マイクロフローリアクター / ビタミンＤ３ |
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| Research Abstract |
Activated vitamin D3 and its analogues are clinically used as drugs for various kinds of diseases including renal failure, osteoporosis, psoriasis, and secondary hyperparathyroidism. Therefore, development of an efficient synthetic method for those compounds is highly important. The most conentional synthesis of vitamin D3 includes photo-reaction and subsequent thermal reaction. The most serious problem with this method is the low selectivity in the photo-reaction. We successfuly developed an efficient micro-flow synthetic method for activated vitamin D3 and its analogues using an inexpensive light source, high-pressure mercury lamp and maicro-flow reactor. We could suppress undesired reaction by performing the problematic photo-reaction in a micro-flow reactor.
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Report
(4 results)
Research Products
(15 results)
