| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Research Abstract |
Activated vitamin D3 and its analogues are clinically used as drugs for various kinds of diseases including renal failure, osteoporosis, psoriasis, and secondary hyperparathyroidism. Therefore, development of an efficient synthetic method for those compounds is highly important. The most conentional synthesis of vitamin D3 includes photo-reaction and subsequent thermal reaction. The most serious problem with this method is the low selectivity in the photo-reaction. We successfuly developed an efficient micro-flow synthetic method for activated vitamin D3 and its analogues using an inexpensive light source, high-pressure mercury lamp and maicro-flow reactor. We could suppress undesired reaction by performing the problematic photo-reaction in a micro-flow reactor.
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