Base metal "Iron"-catalyzed or mediated Preparation of Polyfunctionalized Compounds
| Project/Area Number |
23750102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
HATA Takeshi 東京工業大学, 生命理工学研究科, 准教授 (40419271)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 鉄 / ユビキタス元素 / 官能基共存型反応 / グリニャール試薬 / 多官能性化合物 / 鉄触媒 / 低原子価鉄試薬 / シクロプロパン / ビタミンK / ニトロ化合物 / 官能性エンイン / スルホニルジエン / ペルオキシアセタール / ジマグネシオ体 / 分子内環化反応 |
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| Research Abstract |
This research representative developed various synthetic methodologies of polifunctionalized compounds by using interaction of iron catalyst and functionalized carbon-carbon multiple bonds. Specifically, the following items were carried out. 1) Application of iron-catalyzed selective addition to functionalized dienes of Grignard reagents. 2) Iron-catalyzed selective addition to sulfonyl dienes or functionalized enynes of Grignard reagents. 3) Application of iron-catalyzed selective substitution to functionalized diene monoepoxides of Grignard reagents. 4) Reductive homocoupling reaction of functionalized diene monoepoxides with iron catalyst-stereoselective synthesis of cyclopropanes. 5) Iron-catalyzed selective synthesis of peroxyacetals from benzyl ethers and tert-butyl hydroperoxide. 6) Iron-catalyzed preparation of amines from nitro compounds and Grignard reagents via reductive coupling reaction.
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Report
(4 results)
Research Products
(40 results)
