Development of Novel Carbon-Carbon Bond Forming Reactions for Application to Industrial Process
Project/Area Number |
23750104
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Synthetic chemistry
|
Research Institution | Tokyo Institute of Technology |
Principal Investigator |
AIKAWA Kousuke 東京工業大学, 大学院・理工学研究科, 助教 (30401532)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 不斉合成 / 反応 / 炭素-炭素結合生成反応 / 不斉配位子 / 不斉金属触媒 / エン反応 / オキセテン / 環化付加反応 / Diels-Alder反応 / 医農薬 / 不斉触媒 / イン反応 / 医薬品 |
Research Abstract |
I have succeeded in highly enantioselective and atom-economical reactions, especially [2 + 2] cycloaddition of diverse array of alkynes with trifluoropyruvate using chiral dicationic BINAP-Pd catalyst to provide the unprecedentedly stable oxetene derivatives. The reaction takes place with good-to-excellent yields and various substituents on the internal alkynes. This catalytic process offers not only the first synthetic method of stable oxetene derivatives but also new entry to oxetenes as a novel chiral trifluoromethyl building block for pharmaceuticals and agrochemicals.
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Report
(3 results)
Research Products
(31 results)