Research Project
Grant-in-Aid for Young Scientists (B)
Direct functionalization of sp^3C-H bond adjuscent to nitrogen atom of tertiary amines under photoirradiation has been emerged a particularly attractive synthetic approach for nitrogen-containing compounds. We have recently developed the novel intermolecular addition of α-aminoalkyl radicals with nitrones under photoirradiation in the absence of photosensitizers to give hydroxylamine derivatives. The combined use of photosensitizers and photoirradiation works in a highly effective manner to accelerate reactions of α-aminoalkyl radical with nitrones. Several kinds of nitrones and tertiary amines have been successfully utilized under photosensitized conditions. A multifunctional chiral hybrid Lewis acid-photosensitizer catalyst has been developed and used for the reaction to give the adduct in a good yield. The enantiomeric excess of the product has not been unknown because of difficulties in determination of the optimal conditions for the separation of the enantiomers by chiral HPLC.
All 2013 2012
All Presentation (4 results)
