Development of a Novel Synthetic Method for Chiral NitrogenContaining Compounds under Photoirradiation
Project/Area Number |
23750107
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Synthetic chemistry
|
Research Institution | Shinshu University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 選択的合成 / 反応 / ラジカル / 選択的合成・反応 |
Research Abstract |
Direct functionalization of sp^3C-H bond adjuscent to nitrogen atom of tertiary amines under photoirradiation has been emerged a particularly attractive synthetic approach for nitrogen-containing compounds. We have recently developed the novel intermolecular addition of α-aminoalkyl radicals with nitrones under photoirradiation in the absence of photosensitizers to give hydroxylamine derivatives. The combined use of photosensitizers and photoirradiation works in a highly effective manner to accelerate reactions of α-aminoalkyl radical with nitrones. Several kinds of nitrones and tertiary amines have been successfully utilized under photosensitized conditions. A multifunctional chiral hybrid Lewis acid-photosensitizer catalyst has been developed and used for the reaction to give the adduct in a good yield. The enantiomeric excess of the product has not been unknown because of difficulties in determination of the optimal conditions for the separation of the enantiomers by chiral HPLC.
|
Report
(3 results)
Research Products
(4 results)
-
[Presentation]2013
Author(s)
Itoh, K.; Kato, R.; Suga, H
Organizer
Proceedings of The 93th CSJ Annual Meeting
Place of Presentation
滋賀
Year and Date
2013-03-22
Related Report
-
-
[Presentation]2012
Author(s)
Itoh, K.; Kato, R.; Suga, H
Organizer
Proceedings of The 11th International Symposium on Advanced Technology (ISAT-Special)
Place of Presentation
東京
Year and Date
2012-10-30
Related Report
-