Development of Chiral 1,2,3-Triazolium Salts and Its Application for Catalytic Asymmetric Reactions
| Project/Area Number |
23750110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 有機分子触媒 / イオン対 / オニウム塩 / 1,2,3-トリアゾール / 不斉合成 / トリアゾール / 分子認識 / 触媒的不斉合成 |
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| Research Abstract |
Highly enantioselective chloride and bromide ring openings of meso aziridines with trimethylsilyl halides have been successfully developed by utilizing chiral 1,2,3-triazolium chlorides. The potential utility of the asymmetric halide ring-opening strategy has also been demonstrated by its application to the kinetic resolution of racemic, terminal aziridines. These catalytic asymmetricnucleophilic halogenations based on the use of trimethylsilyl halides rely on the ability of the appropriately modified, chiral 1,2,3-triazolium chloride to generate the requisite halosilicates and extend precise stereocontrol over the halide ion transfer.
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Report
(3 results)
Research Products
(21 results)
