Successive construction of cyclic skeletons via migration of transition metals
| Project/Area Number |
23750115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 選択的合成・反応 / 錯体・有機金属触媒 / 遷移金属触媒反応 / 炭素-水素結合切断 / 炭素-炭素結合切断 / 1,4-ロジウム移動 / 環状骨格構築 / 連続的結合生成 / 有機化学 / 合成化学 / 有機金属化学 / ロジウム / 遷移金属触媒 / 環化反応 / β炭素脱離 / スピロビインダン / ビスシリル化 / η2-ビニルロジウム / シロール / 環状骨格構築反応 |
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| Research Abstract |
1,4-Migration of transition metals is a useful synthetic tool for intramolecular activation of neighboring C-H bonds and has been exploited in the construction of complex organic frameworks. In this study, research on transition-metal-catalyzed reactions involving 1,4-rhodium migration was conducted, and three reactions giving cyclic skeletons were developed. In particular, indanes and spirobiindanes were synthesized by rhodium-catalyzed arylation using arylboron compounds.
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Report
(3 results)
Research Products
(15 results)
