Synthesis of Polymer Membranes with Hierarchically Arrayed ChiralNanopores and Development of Supersmart Separation Ability

• Project/Area Number: 23750121
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Polymer chemistry
• Research Institution: Niigata University
• Principal Investigator: TERAGUCHI Masahiro 新潟大学, 自然科学系, 助教 (30334650)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 機能性高分子 / 多孔質膜 / ナノ空孔 / 不斉転写 / 分離膜 / ポリアセチレン / らせん高分子 / 光学活性高分子 / 脱ピナニルシリル化 / 膜 / 階層構造

Research Abstract

Stereoregular one-handed helical artificial polymers similar to biopolymers such as DNA or enzymes were synthesized and could formed self-supporting membranescomposed of the regular one-handed helical polymers by casting of the polymer solution. By removing of chiral substituents hierarchically arranged along the main chain, self-supporting membranes having nano-pores imprinting of chiral information originated from the chiral substituents could be synthesized. The obtained membrane having chiral imprinted nano-pores showed a optical resolutionability which is promising to application for drug development.

Research Products

• [Journal Article] Helix-Sense-Selective Polymerization of Achiral Phenylacetylenes with Two N-Alkylamide Groups to Generate the One-Handed Helical Polymers Stabilized by Intramolecular Hydrogen Bonds (2012)
  • Author(s): Masahiro Teraguchi,* Daisuke Tanioka, Takashi Kaneko, Toshiki Aoki
  • Journal Title: Macro. Lett. Volume: 1 Issue: 11 Pages: 1258-1261
  • DOI: 10.1021/mz300309c
  • Peer Reviewed
• [Journal Article] Enhanced Gas Permselectivity of Copoly(Hyperbranched Macromonomer) Synthesized by One-pot Simultaneous Copolymerization of Dimethylsilyl-containing Phenylacetylenes (2012)
  • Author(s): Jun Li, Jianjun Wang, Yu Zang, Toshiki Aoki,* Takashi Kaneko, Masahiro Teraguchi
  • Journal Title: Chemistry Letters Volume: 41 Issue: 11 Pages: 1462-1464
  • DOI: 10.1246/cl.2012.1462
  • NAID: 10031126564
  • ISSN: 0366-7022, 1348-0715
  • Peer Reviewed
• [Journal Article] Two Modes of Asymmetric Polymerization of Phenylacetylenes Having an L-Amino Alcohol Residue and Two Hydroxy Groups (2012)
  • Author(s): Hongge Jia, Yu Zang, Jun Li, Toshiki Aoki,* Masahiro Teraguchi, Takashi Kaneko
  • Journal Title: J. Polym. Sci., Part A: Polym. Chem. Volume: 50 Issue: 24 Pages: 5134-5143
  • DOI: 10.1002/pola.26346
  • Peer Reviewed
• [Journal Article] Pseudo helix-sense-selective polymerization of achiral substituted acetylenes (2012)
  • Author(s): Yu Zang, Toshiki Aoki, Lijia Liu, Yunosuke Abe, Yuriko Kakihana, MasahiroTeraguchi, and Takashi Kaneko
  • Journal Title: ChemicalCommunications Volume: 48(39) Issue: 39 Pages: 4761-4763
  • DOI: 10.1039/c2cc00030j
  • Peer Reviewed
• [Journal Article] Synthesis of stable and soluble one-handed helical poly(substituted acetylene)s without chiral pendant groups via polymer reaction in membrane state (2012)
  • Author(s): Yunosuke Abe, Toshiki Aoki,* Hongge Jia, Shingo Hadano, Takeshi Namikoshi, Yuriko Kakihana, Lijia Liu, Yu Zang, Masahiro Teraguchi, Takashi Kaneko
  • Journal Title: POLYMER Volume: 53 Issue: 11 Pages: 2129-2133
  • DOI: 10.1016/j.polymer.2012.03.022
  • Peer Reviewed
• [Journal Article] Transformation from preformed racemic helical poly(phenylacetylene)s to the enantioenriched helical polymers by chiral solvation, followed by removal of the chiral solvents (2012)
  • Author(s): 金子隆司
  • Journal Title: Polymer J. Volume: 2012 Issue: 4 Pages: 327-333
  • DOI: 10.1038/pj.2011.144
  • NAID: 10030516300
  • Peer Reviewed
• [Journal Article] Chiral Teleinduction in Asymmetric Polymerization of 3, 5-Bis (hydroxymethyl)phenylacetylene Having a Chiral Group via a Very Long and Rigid Spacer at 4-Position (2012)
  • Author(s): Abe, Yunosuke; Aoki, Toshiki; Jia, Hongge; Hadano, Shingo; Namikoshi, Takeshi; Kakihana, Yuriko; Liu, Lijia; Zang, Yu; Teraguchi, Masahiro; Kaneko Takashi
  • Journal Title: Chemistry Letters Volume: 41(3) Issue: 3 Pages: 244-246
  • DOI: 10.1246/cl.2012.244
  • NAID: 130004426505
  • Peer Reviewed
• [Journal Article] Synthesis of Stable and Soluble One-handed Helical Homo-poly(substituted acetylene)s without the Coexistence of any Other Chiral Moieties via Two-step Polymer Reactions in Membrane State: Molecular Design for the Starting Monomer (2012)
  • Author(s): Yunosuke Abe, Toshiki Aoki, Hongge Jia, Shingo Hadano, Takeshi Namikoshi, YurikoKakihana, Lijia Liu, Yu Zang, Masahiro Teraguchi, Takashi Kaneko
  • Journal Title: Molecules Volume: 17(1) Issue: 1 Pages: 433-451
  • DOI: 10.3390/molecules17010433
  • Peer Reviewed
• [Journal Article] Enantioselective Pervaporation through Membranes from Poly(1,3-phenyleneethynylenes)-based One-handed Helical Foldamer and Unfoldamer (2011)
  • Author(s): Makoto Inoue, Masahiro Teraguchi, Toshiki Aoki, Takeshi Namikoshi, Edy Marwanta, Takashi Kaneko
  • Journal Title: Chemistry Letters Volume: 40 Pages: 384-386
  • NAID: 10028170631
  • Peer Reviewed
• [Presentation] Optimization of the polymerization conditions of pseudo helix-sense-selective polymerizationand helix-sense-selective polymerization for achiral substituted phenylacetylenes (2012)
  • Author(s): 藏雨、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第61回高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] 膜状態での高分子反応によるパーフルオロアルキル化ポリ(ジフェニルアセチレン)膜の合成と酸素選択透過性 (2012)
  • Author(s): 寺口昌宏、佐藤敬、金子隆司、青木俊樹
  • Organizer: 第61回高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] Helix-sense-selective polymerization of achiral phenylacetylenes having two bulky imino substituents (2012)
  • Author(s): 藏雨、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第61回高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-19
• [Presentation] Pseudohelix-sense-selective polymerization of achiral substituted acetylenes - A new concept and itsrealization - (2012)
  • Author(s): 藏雨、劉立佳、垣花百合子、寺口昌宏、金子隆司 、青木俊樹
  • Organizer: 第61回高分子学会年次大会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2012-05-31
• [Presentation] 置換アセチレンのらせん選択重合(HSSP)の種々の特異な挙動と機構-アキラル制御HSSP、絶対HSSP、自己HSSP、不斉増幅HSSPと機構解明 (2012)
  • Author(s): 菊地一智、田口紗和、和須津郁弥、大石智之、劉立佳、垣花百合子、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第61回高分子学会年次大会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2012-05-29
• [Presentation] Optimization of the polymerization conditions of pseudo helix-sense-selective polymerization and helix-sense-selective polymerization for achiral substituted phenylacetylenes (2012)
  • Author(s): 藏雨、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第61回高分子討論会
  • Place of Presentation: 名古屋
• [Presentation] 膜状態での高分子反応によるパーフルオロアルキル化ポリ（ジフェニルアセチレン）膜の合成と酸素選択透過性 (2012)
  • Author(s): 寺口昌宏、佐藤敬、金子隆司、青木俊樹
  • Organizer: 第61回高分子討論会
  • Place of Presentation: 名古屋
• [Presentation] 置換アセチレンのらせ ん選択重合(HSSP)の種々の特異な挙動と機構－アキラル制御HSSP、絶対HSSP、自己HSSP、不斉増幅HSSPと機構解明 (2012)
  • Author(s): 菊地一智、田口紗和、和須津郁弥、大石智之、劉立佳、垣花百合子、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第61回高分子学会 年次大会
  • Place of Presentation: 横浜
• [Presentation] Pseudo helix-sense-selective polymerization of achiral substituted acetylenes - A new concept and its realization - (2012)
  • Author(s): 雨、劉立佳、垣花百合子、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第61回高分子学会 年次大会
  • Place of Presentation: 横浜
• [Presentation] Pseudohelix-sense-selective polymerization of substituted phenylacetylenes having two hydroxyl groups and a dynamic covalent bond ofimino group (2011)
  • Author(s): 藏雨、大石智之、垣花百合子、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山
  • Year and Date: 2011-09-28
• [Presentation] L-アミノ酸を配位子に有する構造明確な単離Rh錯体によるフェニルアセチレンのらせん選択重合の精密化 (2011)
  • Author(s): 大石智之、垣花百合子、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山
  • Year and Date: 2011-09-28
• [Presentation] 2つの水酸基を持つアキラルなフェニルアセチレンモノマーのキラル触媒系を用いたらせん選択重合の高度化 (2011)
  • Author(s): 菊地一智、大石智之、垣花百合子、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山
  • Year and Date: 2011-09-28
• [Presentation] 2つのビニル基を有するフェニルアセチレンのらせん選択重合(HSSP)体のADMET後重合による片巻きらせんヘテロラダーポリマーの合成とHSSP体主鎖の選択分解 (2011)
  • Author(s): 棚木宏幸、江良康貴、大石智之、垣花百合子、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山
  • Year and Date: 2011-09-28
• [Presentation] 有機蒸気によるキラルなメンチル基を有するポリ(m-フェニレンエチニレン)のらせん構造の膜状態での刺激応答性 (2011)
  • Author(s): 井上真、大石智之、垣花百合子、寺口昌宏、金子隆司、青木俊樹
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: グランキューブ大阪