| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The applicant has expanded his work to polymer-based supramolecular sensing of bio-related materials. To develop a chirality sensing system based on polythiophene, a permethylated cyclodextrin was attached to monothiophene unit with a hexamethylene spacer,which was then polymerized to give novel functional polythiophenes with chirality recognition sites. The cyclodextrin-appended polythiophene showed high enantioselectivity of 13.7 for phenylalanine dipeptide.
To further achieve a more difficult task by constructing a saccharide sensor operative in aqueous media, the applicant employed polysaccharide curdlan (Cur) as a hydrogen-bonding saccharide receptor. Thus, the saccharide sensing by using native Cur/polythiophene complex hybridized in situ as a signal-amplifying reporter enabled us to selectively sense acarbose among 24 mono-, di-, tri, tetra-, and pentasaccharides.
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