Development of functional crystalline materialsbased on host-guest chemistry in the crystalline state

• Project/Area Number: 23750146
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional materials chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: INOKUMA Yasuhide 東京大学, 大学院・工学系研究科, 助教 (80555566)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 細孔性錯体 / X線結晶構造解析 / 固相反応 / ホスト-ゲスト化学 / 単結晶

Research Abstract

A new method (crystalline sponge method) for single crystal X-ray analysis of scarce amount of compounds has been developed based on host-guest chemistry in the crystalline state. This protocol is available for the structural determination of a lot of trace samples such as natural products.

Research Products

• [Journal Article] X-ray analysis on the nanogram to microgram scale using porous complexes (2013)
  • Author(s): Y. Inokuma, S. Yoshioka, J. Ariyoshi, T. Arai, Y. Hitora, K. Takada, S. Matsunaga, K. Rissanen, M. Fujita
  • Journal Title: Nature Volume: 495巻 Pages: 461-466
  • Peer Reviewed
• [Journal Article] X-ray analysis on the nanogram to microgram scale using porous complexes (2013)
  • Author(s): Y. Inokuma, S. Yoshioka, J. Ariyoshi, T. Arai, Y. Hitora, et al.
  • Journal Title: Nature Volume: 495 Issue: 7442 Pages: 461-466
  • DOI: 10.1038/nature11990
  • Peer Reviewed
• [Journal Article] Reagent-Installed Capsule Network: Selective Thiocarbamoylation of Aromatic Amines in Crystals with Pre-installed CH3NCS (2012)
  • Author(s): Y. Inokuma, G.-H. Ning, M. FujitaAngew
  • Journal Title: Chem. Int. Ed Volume: 51 Pages: 2379-2381
  • Peer Reviewed
• [Journal Article] Reagent-Installed Capsule Network: Selective Thiocarbamoylation of Aromatic Amines in Crystals with Pre-installed CH3NCS (2012)
  • Author(s): Yasuhide Inokuma, Guo-Hong Ning, Makoto Fujita
  • Journal Title: Angewandte Chemie International Edition Volume: 51 Issue: 10 Pages: 2379-2381
  • DOI: 10.1002/anie.201107190
  • Peer Reviewed
• [Journal Article] Shedding Light on Hidden Reaction Pathways in Radical Polymerization by a Porous Coordination Network (2011)
  • Author(s): Y. Inokuma, S. Nishiguchi, K. Ikemoto, M. Fujita
  • Journal Title: Chem. Commun Volume: 47 Pages: 12113-12115
  • Peer Reviewed
• [Journal Article] Diels-Alder via Molecular Recognition in a Crystalline Molecular Flask (2011)
  • Author(s): K. Ikemoto, Y. Inokuma, M. Fujita
  • Journal Title: J. Am. Chem. Soc Volume: 133 Pages: 16806-16808
  • Peer Reviewed
• [Journal Article] Bimolecular Reaction via the Successive Introduction of Two Substrates into the Crystals of Networked Molecular Cages (2011)
  • Author(s): Y. Inokuma, N. Kojima, T. Arai, M. Fujita
  • Journal Title: J. Am. Chem. Soc Volume: 133 Pages: 19691-19693
  • Peer Reviewed
• [Journal Article] Crystalline Molecular Flasks (2011)
  • Author(s): Y. Inokuma, M. Kawano, M. Fujita
  • Journal Title: Nature Chem Volume: 3 Pages: 349-358
  • Peer Reviewed
• [Journal Article] Crystalline Molecular Flasks (2011)
  • Author(s): Yasuhide Inokuma, Masaki Kawano, Makoto Fujita
  • Journal Title: Nature Chemistry Volume: 3 Issue: 5 Pages: 349-358
  • DOI: 10.1038/nchem.1031
  • Peer Reviewed
• [Journal Article] Shedding Light on Hidden Reaction Pathways in Radical Polymerization by a Porous Coordination Network (2011)
  • Author(s): Inokuma, Y.; Nishiguchi, S.; Ikemoto, K.; Fujita, M.
  • Journal Title: Chemical Communication Volume: 47 Issue: 44 Pages: 12113-12115
  • DOI: 10.1039/c1cc15053g
  • Peer Reviewed
• [Journal Article] Diels-Alder via Molecular Recognition in a Crystalline Molecular Flask (2011)
  • Author(s): Ikemoto, K.; Inokuma, Y.; Fujita, M.
  • Journal Title: Journal of the American Chemical Society Volume: 133 Issue: 42 Pages: 16806-16808
  • DOI: 10.1021/ja2079064
  • Peer Reviewed
• [Journal Article] Bimolecular Reaction via the Successive Introduction of Two Substrates into the Crystals of Networked Molecular Cages (2011)
  • Author(s): Yasuhide Inokuma, Nodoka Kojima, Tatsuhiko Arai, Makoto Fujita
  • Journal Title: Journal of the American Chemical Society Volume: 133 Issue: 49 Pages: 19691-19693
  • DOI: 10.1021/ja209290t
  • Peer Reviewed
• [Presentation] 細孔性結晶を用いたマイクログラムスケールの天然物X線結晶構造解析 (2013)
  • Author(s): 猪熊泰英、有吉絢子、吉岡翔太、高田健太郎、松永茂樹、藤田誠
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス(滋賀県)
  • Year and Date: 2013-03-25
• [Presentation] 細孔性結晶を用いたマイクログラムスケールの天然物Ｘ線結晶構造解析 (2013)
  • Author(s): 猪熊泰英、有吉絢子、吉岡翔太、高田健太郎、松永茂樹、藤田誠
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学(滋賀県)
• [Presentation] Networked molecular cages and capsules as crystalline hosts for guest encapsulation and reactions (2012)
  • Author(s): Yasuhide Inokuma, Makoto Fujita
  • Organizer: 3rd International Conference onMetal-Organic Frameworks and OpenFramework
  • Place of Presentation: the University of Edinburgh (スコットラン ド)
  • Year and Date: 2012-09-17
• [Presentation] Solution-like chemistry in crystals of networked molecular hosts (2012)
  • Author(s): Yasuhide Inokuma, Makoto Fujita
  • Organizer: 4th EuCheMS Chemistry Congress
  • Place of Presentation: Prague Congress Centre (チェコ)
  • Year and Date: 2012-08-28
• [Presentation] Solution-like chemistry in crystals of networked molecular hosts (2012)
  • Author(s): Yasuhide Inokuma, Makoto Fujita
  • Organizer: 4th EuCheMS Chemistry Congress
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Networked molecular cages and capsules as crystalline hosts for guest encapsulation and reactions (2012)
  • Author(s): Yasuhide Inokuma, Makoto Fujita
  • Organizer: 3rd International Conference on Metal-Organic Frameworks and Open Framework
  • Place of Presentation: Edinburgh, United Kingdom
• [Presentation] Host-Guest Chemistry in Crystals of Networked Molecular Cages (2011)
  • Author(s): Yasuhide Inokuma, Makoto Fujita
  • Organizer: 11th Tateshina Conference on Organic Chemistry
  • Place of Presentation: 蓼科フォーラム(長野県)
  • Year and Date: 2011-11-12
• [Presentation] 細孔性ネットワーク錯体をホストに用いた結晶内2分子反応"錯体化学会 (2011)
  • Author(s): 猪熊泰英、小嶋和、寧國宏、藤田誠
  • Organizer: 第61回討論会
  • Place of Presentation: 岡山理科大学(岡山県)
  • Year and Date: 2011-09-17
• [Presentation] 細孔性ネットワーク錯体をホストに用いた結晶内2分子反応
  • Author(s): 猪熊泰英、小嶋 和、寧 國宏、藤田 誠
  • Organizer: 錯体化学会 第６１回討論会
  • Place of Presentation: 岡山理科大学（岡山県）
• [Presentation] Host-Guest Chemistry in Crystals of Networked Molecular Cages
  • Author(s): Yasuhide Inokuma, Makoto Fujita
  • Organizer: 11th Tateshina Conference on Organic Chemistry
  • Place of Presentation: 蓼科フォーラム（長野県）
• [Remarks]
  • URL: http://fujitalab.t.u-tokyo.ac.jp/members/yinokuma/
• [Remarks]
  • URL: http://fujitalab.t.u-tokyo.ac.jp/members/yinokuma/