Molecular-targeted nanobubbles for ultrasound contrast agents using a newly synthesized surfactant
Project/Area Number |
23750168
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Functional materials chemistry
|
Research Institution | Tokyo University of Science |
Principal Investigator |
TSUCHIYA Koji 東京理科大学, 理学部, 助教 (50398822)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ナノバブル / 超音波診断 / 造影剤 / 分子認識 / シクロアミロース修飾界面活性剤 / リン脂質 / ガラクトース / 葉酸 / ジェミニ型界面活性剤 |
Research Abstract |
The present study aims to develop molecular-targeted ultrasound contrast agents (nanobubbles) using a newly synthesized cycloamylose-modified surfactant (CA-LA). Nanobubbles with high dispersion stability in blood serum can be obtained using mixed CA-LA and a polyethylene glycol (PEG)-modified phospholipid as the dispersion agents. The labeling of folic acid to the nanobubbles enhances their accumulation to KB cells having folate receptors. Galactose-labeled nanobubbles are selectively accumulated to human liver tumor cells (HepG2), in which asialoglycoprotein receptors are generated. The results reveal that the nanobubbles obtained in the present study can be a useful ultrasound contrast agent having high stability in blood and high accumulation ability to tumor cells.
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Report
(4 results)
Research Products
(32 results)