| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
|---|
| Research Abstract |
A novel catalytic system using a peptide catalyst and an enzyme in one-pot was developed. By combining the activation with the peptide having a terminal amino group and air oxidation with the enzyme, asymmetric alpha-oxyamination of saturated aldehydes was realized. This was extended to the sequential reaction, in which alpha,beta-unsaturated aldehydes were efficiently converted to highly functionalized products in one-pot.
|
