Development of environmentally benign systems by combiniengzymaen and organocatalyst
| Project/Area Number |
23750171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AKAGAWA Kengo 東京大学, 生産技術研究所, 助教 (60548733)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | ペプチド触媒 / 有機触媒 / 酸化酵素 / 不斉合成 / 連続反応 / ラッカーゼ / 不斉酸化反応 / オキシアミノ化反応 |
|---|
| Research Abstract |
A novel catalytic system using a peptide catalyst and an enzyme in one-pot was developed. By combining the activation with the peptide having a terminal amino group and air oxidation with the enzyme, asymmetric alpha-oxyamination of saturated aldehydes was realized. This was extended to the sequential reaction, in which alpha,beta-unsaturated aldehydes were efficiently converted to highly functionalized products in one-pot.
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Report
(3 results)
Research Products
(29 results)
