Application of side-chain cross-linked helical peptides having photoreactive groups to biotools
| Project/Area Number |
23750184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyushu Sangyo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | α-ヘリックス / 架橋ペプチド / 光反応部位 / ジアリールエテン / 光制御 / α‐ヘリックス / 光機能 / 化学修飾 |
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| Research Abstract |
I developed photoresponsive helical peptides bridged with a diarylethene-based cross-linking agenet on the basis of the binding domains of DNA-binding proteins. Quartz crystal microbalance (QCM) analysis showed real-time monitoring that DNA-peptide interaction was photoregulated with a fluorescent lamp. Additionally, diarylethene-based non-natural amino acids were developed and were introduced into shortpeptides.
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Report
(3 results)
Research Products
(22 results)
