Coordination chemistry to clinical applications-development of MRI probes based on redox chemistry of metal complexes
| Project/Area Number |
23750195
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemistry related to living body
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分子プローブ / MRI / イメージング / 低酸素微小環境 / 金属錯体 / 生体関連化学 / in vivo |
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| Research Abstract |
The purpose of this project is to develop new MRI imaging probes that enable non-invasive visualization of hypoxic region in tumor. To this end, we tried to create hypoxia cleavable linker molecules by taking advantages of the redox activity and ligand exchanging property of a cobalt complex. Moreover, the hypoxia-selective linker was combined with a gadlinium complex or a fluorine-containing compound to achieve hypoxia-selective MRI contract agents.
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Report
(3 results)
Research Products
(12 results)
