Control of formation of molecular assembly using artificial hydrophobic cavity in DNA
| Project/Area Number |
23750198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemistry related to living body
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| Research Institution | University of Hyogo |
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Principal Investigator |
TAKADA Tadao 兵庫県立大学, 工学(系)研究科(研究院), 助教 (60511699)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | DNA / 光電子移動反応 / 蛍光センサー / 光電流 / 分子デバイス / 超分子化学 / 電子移動 / 機能性色素 / 超分子 / 発光 / ナノデバイス |
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| Research Abstract |
We have established a convenient way to construct the molecular assembly of functional dyes within DNA using an artificial hydrophobic pocket created in DNA by replacing nucleotides with abasic site analogs. We also investigated the photochemical properties of the molecular assembly in the complex composed of DNA and the functional dyes. The facially stacked functional dyes in DNA were found to generate a long-lived charge separated state by photo excitation and display photocurrent with high efficiency. We have also developed the fluorescence sensor for the target nucleic acid or metal ions using the unique binding behavior of the hydrophobic fluorescent dyes to the mutation sites in DNA.
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Report
(4 results)
Research Products
(18 results)
