| Project/Area Number |
23750233
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Inorganic industrial materials
|
|---|
| Research Institution | Iwate University |
|---|
Principal Investigator |
AISAWA Sumio 岩手大学, 工学研究科, 助教 (40333752)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 層状・層間化合物 / ドラッグデリバリーシステム / 抗がん剤 / カーボンナノスフィア / 細胞毒性 / 層状複水酸化物 / ドラッグデリバリー材料 / 中空ナノスフィア / 細胞増殖抑制効果 / ナノ材料 / 無機工業化学 |
|---|
| Research Abstract |
Layered double hydroxide (LDH) has been considerable attentions as materials for drug delivery in pharmaceutical field. In this study, the synthesis of LDH nanosphere (LDH-NS) by using carbon nanosphere template and the intercalation of anticancer drug, 5-fluorouracil (5-FU), into the LDH-NS by the reconstruction method have been investigated in order to promote the cellular uptake of 5-FU. The XRD patterns of the 5-FU/LDH-NS showed that the interlayer distance was expanded with the intercalation of 5-FU. The results of HeLa cytotoxicity assay indicated that the 5-FU/LDH-NS performed well cytostatic effect, which is three times higher than that of 5-FU.
|
