Gene carriers containing functional peptides for breast cancer treatment
| Project/Area Number |
23750264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer/Textile materials
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NUMATA Keiji 独立行政法人理化学研究所, 酵素研究チーム, チームリーダー (40584529)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ペプチド / シルク / 遺伝子デリバリー / 癌細胞 |
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| Research Abstract |
Nano-scale complexes of fusion peptides to contain tumor homing peptides with plasmid DNA (pDNA) are designed as less-cytotoxic and highly target-specific gene carriers. The fusion peptide containing Lyp1 showed significant differences from fusion peptide containing F3 in cytotoxicity to MCF10A cells, and the fusion peptide containing F3 is therefore considered to be the most useful candidate for target delivery into tumorigenic cells. The target specificity of the pDNA complexes to tumorigenic cells was also found to be regulated by specific adsorption process on the cell surface.
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Report
(3 results)
Research Products
(30 results)
