Fabrication of a real-time mechanical stimulus response evaluation microdevice for stem cell differentiation induction
| Project/Area Number |
23760232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NAKASHIMA Yuta 山口大学, 大学院・理工学研究科, 助教 (70574341)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 機械刺激 / リアルタイム評価 / 分化誘導 / バイオMEMS / 細胞刺激 / リアルタイム細胞観察 / マイクロデバイス / BioMEMS |
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| Research Abstract |
A real-time mechanical stimulus response evaluation microdevice for differentiation induction of stem cells was fabricated using MEMS technology. The device design, fabrication conditions, and process conditions were determined, and the validity of proposed design and fabrication process of the microdevice was proved. Also, the drive performance of the fabricated microdevice was evaluated. Moreover, deformation behavior and intracellular calcium concentration change of cells to receive the mechanical stimuli on the fabricated microdevice were observed in real time.
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Report
(3 results)
Research Products
(9 results)
