• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of surgery probe of deep brain stimulation integrated with CMOS microchips

Research Project

Project/Area Number 23760312
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Electron device/Electronic equipment
Research InstitutionNara Institute of Science and Technology

Principal Investigator

NODA Toshihiko  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (20464159)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsCMOS集積回路 / 刺入型デバイス / 電気刺激 / 電位計測 / スマート電極 / フレキシブルデバイス / CMOS / 神経刺激 / 神経計測 / 刺入型電極 / 神経活動計測 / 生体埋植
Research Abstract

A novel clinical medical tool for surgical operation of deep brain stimulation was fabricated and evaluated. Dedicated micro-CMOS image sensor was mounted on the tip of quite fine probe tube. The probe has the same diameter as a probe that is utilized in surgical operation. In this study, stimulation and recording function of nerve were also integrated into the CMOS microchip. The CMOS microchips were assembled onto a flexible substrate with stimulus/recording electrodes. A prototype of proposed device was developed successfully, and functional evaluation was performed.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (17 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Performance improvement and functionalization of an electrode array for retinal prosthesis by iridium oxide coating and introduction of smart-wiring technology using CMOS microchips2014

    • Author(s)
      T. Noda, K. Sasagawa, T. Tokuda, Y. Terasawa, H. Takashiro, H. Kanda, T. Fujikado, and J. Ohta
    • Journal Title

      Sensors and Actuators A: Physcal

      Volume: 211 Pages: 27-37

    • DOI

      10.1016/j.sna.2014.03.001

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sputtering Condition Optimization of Sputtered IrOx and TiN Stimulus Electrodes for Retinal Prosthesis2013

    • Author(s)
      Yi-Li Pan, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Journal Title

      電気学会論文誌

      Volume: 8 Issue: 3 Pages: 310-312

    • DOI

      10.1002/tee.21860

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smart electrode array device with CMOS multi-chip architecture for neural interface2012

    • Author(s)
      Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yasuo Terasawa, Hiroyuki Tashiro, Hiroyuki Kanda, Takashi Fujikado, Jun Ohta
    • Journal Title

      Electronics Letters

      Volume: 48(21) Issue: 21 Pages: 1328-1329

    • DOI

      10.1049/el.2012.2784

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimization of Sputtering Condition of IrOx Thin Film Stimulation Electrode for Retinal Prosthesis Application2012

    • Author(s)
      Yi-Li Pan, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Hiroyuki Kanda, Takashi Fujikado, Jun Ohta
    • Journal Title

      Journal of Physics : Conference Series

      Volume: 352(12005) Pages: 1-8

    • DOI

      10.1088/1742-6596/352/1/012005

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of in situ Imaging Probe for Surgical Operation of Deep Brain Stimulation2011

    • Author(s)
      T.Noda, P.Yi-Li, A.Tagawa, T.Kobayashi, K.Sasagawa, T.Tokuda, Y.Hatanaka, N.Nakano, A.Kato, S.Shiosaka, J.Ohta
    • Journal Title

      IEEJ Transactions on Sensors and Micromachines

      Volume: 131 Issue: 12 Pages: 427-428

    • DOI

      10.1541/ieejsmas.131.427

    • NAID

      10030533281

    • ISSN
      1341-8939, 1347-5525
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳深部構造のイメージングの試み2011

    • Author(s)
      中野直樹,加藤天美,野田俊彦,太田淳,徳田崇,塩坂貞夫,畠中由美子
    • Journal Title

      機能的脳神経外科別冊

      Volume: 50(2) Pages: 146-149

    • NAID

      10029745742

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳深部刺激手術用in situ イメージングプローブの開発2011

    • Author(s)
      野田 俊彦, Pan Yi-Li, 田川 礼人, 小林 琢磨, 笹川 清隆, 徳田 崇, 畠中 由美子, 中野 直樹, 加藤 天美, 塩坂 貞夫, 太田 淳
    • Journal Title

      電気学会論文誌E(センサ・マイクロマシン部門誌)

      Volume: 131 Pages: 427-428

    • NAID

      10030533281

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 脳深部構造のイメージングの試み2011

    • Author(s)
      中野 直樹,加藤 天美,野田 俊彦,太田 淳,徳田 崇,塩坂 貞夫,畠中 由美子
    • Journal Title

      機能的脳神経外科 別冊

      Volume: 50 Pages: 146-149

    • NAID

      10029745742

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Intelligent Retinal Prosthetic Device Employs Smart Electrode Array Integrated with CMOS Microchips,International Conference on BioSensors, BioElectronics, BioMedical Devices2013

    • Author(s)
      Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yasuo Terasawa, Hiroyuki Tashiro, Hiroyuki Kanda, Takashi Fujikado, Jun Ohta
    • Organizer
      BioMEMS/NEMS and Applications 2013 (Bio4Apps 2013)
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] CMOSチップを電極内部に組込んだ人工視覚用スマート電極アレイの作製2013

    • Author(s)
      藤本裕介,黒木渉平,野田俊彦,笹川清隆,徳田崇,寺澤靖雄,太田淳
    • Organizer
      応用物理学会秋季学術講演会
    • Place of Presentation
      同志社大学京田辺キャンパス
    • Year and Date
      2013-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 脊髄刺激・計測用CMOSチップ搭載スマート電極デバイスの作製と機能実証2013

    • Author(s)
      黒木渉平,東丸幸江,平松祐樹,藤本裕介,野田俊彦,笹川清隆,徳田崇,金祉希,関和彦,太田淳
    • Organizer
      応用物理学会春季講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2013-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Intelligent Retinal Prosthetic Device Employs Smart Electrode Array Integrated with CMOS Microchips2013

    • Author(s)
      Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Yasuo Terasawa, Hiroyuki Tashiro, Hiroyuki Kanda, Takashi Fujikado, Jun Ohta
    • Organizer
      International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS and Applications 2013 (Bio4Apps 2013)
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] CMOSチップを電極内部に組込んだ人工視覚用スマート電極アレイの作製2013

    • Author(s)
      藤本 裕介, 黒木 渉平, 野田 俊彦, 笹川 清隆, 徳田 崇, 寺澤 靖雄, 太田 淳
    • Organizer
      応用物理学会秋季学術講演会
    • Place of Presentation
      同志社大学 京田辺キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Smart Electrode Array Devices with CMOS Microchip for Neural Interface2012

    • Author(s)
      Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      International Conference on BioElectornics, BioSensors, Biomedical Devices, BioMEMS/NEMS and Applications 2012 (Bio4Apps 2012)
    • Place of Presentation
      National University of Singapore(Oral Presentation 8)
    • Year and Date
      2012-11-20
    • Related Report
      2013 Final Research Report
  • [Presentation] CMOSチップを搭載した脊髄刺激・計測デバイスの作製と機能評価2012

    • Author(s)
      東丸幸江,平松祐樹,野田俊彦,笹川清隆,徳田崇,関和彦,太田淳
    • Organizer
      応用物理学会学術講演会
    • Place of Presentation
      愛媛大学
    • Year and Date
      2012-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Flexible Retinal Prosthesis Device with CMOS Micorochip2012

    • Author(s)
      Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      CMOS-Emerging Technology 2012
    • Place of Presentation
      Vancouver, CANADA
    • Year and Date
      2012-07-18
    • Related Report
      2013 Final Research Report
  • [Presentation] CMOSチップを搭載した刺入型刺激・計測デバイスの作製2012

    • Author(s)
      東丸幸江,伊藤卓祐,北尾拓也,平松祐樹,野田俊彦,笹川清隆,徳田崇,太田淳
    • Organizer
      応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-03-16
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] CMOSチップ搭載脳刺激・計測用インテリジェント電極アレイの作製2011

    • Author(s)
      伊藤卓祐,北尾拓也,野田俊彦,笹川清隆,徳田崇,太田淳
    • Organizer
      応用物理学会学術講演会
    • Place of Presentation
      山形大学
    • Year and Date
      2011-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] CMOSチップ搭載インテリジェント生体インターフェースデバイス2011

    • Author(s)
      野田俊彦,北尾拓也,伊藤卓祐,笹川清隆,徳田崇,神田寛行,田代洋行,寺澤靖雄,不二門尚,太田淳
    • Organizer
      バイオ・マイクロシステム研究会(BMS研究会)
    • Place of Presentation
      東京工業大学
    • Year and Date
      2011-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] CMOSチップ搭載 脳刺激・計測用インテリジェント電極アレイの作製2011

    • Author(s)
      伊藤 卓祐, 北尾 拓也, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
    • Organizer
      応用物理学会学術講演会
    • Place of Presentation
      山形大学
    • Related Report
      2011 Research-status Report
  • [Presentation] CMOSチップ搭載インテリジェント生体インターフェースデバイス2011

    • Author(s)
      CMOSチップ搭載インテリジェント生体インターフェースデバイス
    • Organizer
      電気学会E部門バイオ・マイクロシステム研究会
    • Place of Presentation
      東京工業大学
    • Related Report
      2011 Research-status Report
  • [Presentation] A Smart Electrode Array Devices with CMOS Microchip for Neural Interface

    • Author(s)
      Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      International Conference on BioElectornics, BioSensors, Biomedical Devices, BioMEMS/NEMS and Applications 2012
    • Place of Presentation
      National University of Singapore
    • Related Report
      2012 Research-status Report
  • [Presentation] Flexible Retinal Prosthesis Device with CMOS Micorochip

    • Author(s)
      Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      CMOS-Emerging Technology 2012
    • Place of Presentation
      Vancouver, CANADA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 脊髄刺激・計測用CMOS チップ搭載スマート電極デバイスの作製と機能実証

    • Author(s)
      黒木 渉平, 東丸 幸江, 平松 祐樹, 藤本 裕介, 野田 俊彦, 笹川 清隆, 徳田 崇, 金 祉希, 関 和彦, 太田 淳
    • Organizer
      応用物理学会春季講演会
    • Place of Presentation
      神奈川工科大学
    • Related Report
      2012 Research-status Report
  • [Presentation] CMOSチップを搭載した脊髄刺激・計測デバイスの作製と機能評価

    • Author(s)
      東丸 幸江, 平松 祐樹, 野田 俊彦, 笹川 清隆, 徳田 崇, 関 和彦, 太田 淳
    • Organizer
      応用物理学会学術講演会
    • Place of Presentation
      愛媛大学
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 生体用高機能電極生体用高機能電極2013

    • Inventor(s)
      野田 俊彦,徳田 崇,笹川 清隆,太田 淳
    • Industrial Property Rights Holder
      奈良先端科学技術大学院大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-028006
    • Filing Date
      2013-02-15
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 生体用高機能電極生体用高機能電極2013

    • Inventor(s)
      野田 俊彦,徳田 崇,笹川 清隆,太田 淳
    • Industrial Property Rights Holder
      奈良先端科学技術大学院大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-028006
    • Filing Date
      2013-02-15
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi